{
  "id": 11018,
  "label": "multicentric osteolysis, nodulosis, and arthropathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009809",
  "properties": {
    "xrefs": [
      "GARD:0013743",
      "NCIT:C123437",
      "OMIM:259600"
    ],
    "synonyms": [
      "Al-Aqeel Sewairi syndrome",
      "MONA",
      "MONA, MMP2-related",
      "NAO syndrome",
      "Torg syndrome",
      "Winchester-Torg syndrome",
      "multicentric osteolysis, nodulosis and arthropathy, MMP2-related",
      "multicentric osteolysis, nodulosis, and arthropathy",
      "nodulosis-arthropathy-osteolysis syndrome",
      "osteolysis, hereditary multicentric",
      "Torg-Winchester syndrome",
      "Torg-Winchester syndrome, formerly"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "A rare, autosomal recessive inherited syndrome caused by mutations in the MMP2 gene. It is characterized by the presence of multiple, painless subcutaneous nodules, osteolysis particularly in the hands and feet, osteoporosis, and arthropathy."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 18398,
      "label": "multicentric osteolysis-nodulosis-arthropathy spectrum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19478
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017610",
          "MEDGEN:342428",
          "Orphanet:371428",
          "SCTID:716868003",
          "UMLS:C1850155"
        ],
        "synonyms": [
          "MONA spectrum"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A rare genetic chronic skeletal disorder characterized by peripheral osteolysis (especially carpal and tarsal bones), interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018298"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 18398,
      "label": "multicentric osteolysis-nodulosis-arthropathy spectrum"
    }
  ]
}