{
  "id": 11021,
  "label": "chronic recurrent multifocal osteomyelitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0009813",
  "properties": {
    "xrefs": [
      "DOID:0060645",
      "GARD:0006108",
      "HP:0002754",
      "ICD10CM:M86.3",
      "MEDGEN:140822",
      "MESH:C535456",
      "NANDO:1200869",
      "NANDO:2200438",
      "NCIT:C119042",
      "OMIMPS:609628",
      "Orphanet:324964",
      "SCTID:240151005",
      "UMLS:C0410422",
      "icd11.foundation:1256384247"
    ],
    "synonyms": [
      "CNO/CRMO",
      "CRMO",
      "NBO",
      "chronic multifocal osteomyelitis",
      "chronic recurrent multifocal osteomyelitis",
      "chronic recurrent multifocal osteomyelitis (disease)",
      "non-bacterial osteomyelitis",
      "CMO",
      "chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis",
      "multifocal osteomyelitis, chronic",
      "osteomyelitis, chronic multifocal"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Chronic non bacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), is a chronic autoinflammatory syndrome that is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6951,
      "label": "osteomyelitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4665,
        5177
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1019",
          "EFO:0003102",
          "GARD:0007286",
          "HP:0002754",
          "ICD10CM:M86",
          "ICD10WHO:M86",
          "ICD9:730.0",
          "ICD9:730.01",
          "ICD9:730.1",
          "ICD9:730.10",
          "ICD9:730.11",
          "ICD9:730.20",
          "ICD9:730.28",
          "ICD9:730.92",
          "ICD9:730.93",
          "ICD9:730.94",
          "ICD9:730.96",
          "ICD9:730.97",
          "MEDGEN:10497",
          "MESH:D010019",
          "NCIT:C27577",
          "SCTID:60168000",
          "UMLS:C0029443"
        ],
        "synonyms": [
          "osteomyelitis",
          "osteomyelitis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005246"
    },
    {
      "id": 19503,
      "label": "autoinflammatory syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        7203
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0051000",
          "ICD10CM:M04-M04",
          "MEDGEN:855741",
          "MedDRA:10072220",
          "NANDO:2100156",
          "NCIT:C119050",
          "Orphanet:93665",
          "UMLS:C3890737"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A group of disorders of the innate immune system characterized by attacks of seemingly unprovoked inflammation without significant levels of either autoantibodies or autoreactive T cells more characteristic of autoimmune disease."
      },
      "child_count": 74,
      "reference_id": "MONDO:0019751"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:473110",
          "NCIT:C97075",
          "SCTID:363045008",
          "UMLS:C0410787"
        ],
        "synonyms": [
          "Mendelian connective tissue disorder",
          "connective tissue hereditary disorder",
          "hereditary connective tissue disorder",
          "Hereditary Connective Tissue Disorder",
          "Inherited disorder of connective tissue",
          "inherited disorder of connective tissue"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "An inherited genetic disorder that affects the connective tissues. Representative examples include Ehlers-Danlos syndrome and Marfan syndrome."
      },
      "child_count": 176,
      "reference_id": "MONDO:0023603"
    }
  ],
  "children": [
    {
      "id": 13372,
      "label": "Majeed syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11021
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061224",
          "GARD:0010088",
          "ICD9:759.89",
          "MEDGEN:351273",
          "MESH:C537839",
          "MedDRA:10072223",
          "NANDO:2200453",
          "NCIT:C119058",
          "OMIM:609628",
          "Orphanet:77297",
          "SCTID:703540008",
          "UMLS:C1864997",
          "icd11.foundation:1316564349"
        ],
        "synonyms": [
          "Majeed syndrome",
          "chronic recurrent multifocal osteomyelitis-congenital dyserythropoietic anemia-neutrophilic dermatosis syndrome",
          "CDA and CRMO",
          "MAJEED syndrome",
          "MJDS",
          "chronic recurrent multifocal osteomyelitis, congenital",
          "chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic Anemia, and neutrophilic dermatosis",
          "congenital dyserythropoietic anaemia and chronic recurrent multifocal osteomyelitis",
          "congenital dyserythropoietic anemia and chronic recurrent multifocal osteomyelitis",
          "dyserythropoietic anemia, and neutrophilic dermatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Majeed syndrome is a rare genetic multisystemic disorder characterized by the triad of chronic recurrent multifocal osteomyelitis, congenital dyserythropoietic anemia, and variable transient inflammatory dermatosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012316"
    },
    {
      "id": 14059,
      "label": "sterile multifocal osteomyelitis with periostitis and pustulosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11021
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061225",
          "GARD:0010516",
          "MEDGEN:411230",
          "MESH:C557815",
          "NANDO:2200439",
          "NCIT:C119056",
          "OMIM:612852",
          "Orphanet:210115",
          "UMLS:C2748507"
        ],
        "synonyms": [
          "DIRA",
          "Interleukin-1 receptor antagonist deficiency",
          "OMPP",
          "autoinflammatory disease due to interleukin-1 receptor antagonist deficiency",
          "deficiency of the Interleukin-1 receptor antagonist",
          "Interleukin 1 receptor antagonist deficiency",
          "deficiency of interleukin-1 receptor antagonist",
          "osteomyelitis, STERILE multifocal, with periostitis and pustulosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An autoinflammatory disease caused by mutations in the IL1RN gene, which encodes the IL1 receptor antagonist. It presents in infancy, and is characterized by systemic inflammation, pustular rash, bone pain, sterile osteitis, and periostitis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013021"
    },
    {
      "id": 25851,
      "label": "chronic recurrent multifocal osteomyelitis 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11021
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026955",
          "OMIM:259680"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958177"
    }
  ],
  "roots": [
    {
      "id": 6951,
      "label": "osteomyelitis"
    },
    {
      "id": 19503,
      "label": "autoinflammatory syndrome"
    },
    {
      "id": 21247,
      "label": "hereditary disorder of connective tissue"
    }
  ]
}