{
  "id": 11237,
  "label": "hereditary spastic paraplegia 15",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010044",
  "properties": {
    "xrefs": [
      "DOID:0110768",
      "GARD:0009581",
      "MEDGEN:341387",
      "MESH:C536642",
      "OMIM:270700",
      "Orphanet:100996",
      "SCTID:709417000",
      "UMLS:C1849128"
    ],
    "synonyms": [
      "Kjellin syndrome",
      "SPG15",
      "ZFYVE26 autosomal recessive complex spastic paraplegia",
      "autosomal recessive complex spastic paraplegia caused by mutation in ZFYVE26",
      "autosomal recessive spastic paraplegia type 15",
      "hereditary spastic paraparesis type 15",
      "hereditary spastic paraplegia 15",
      "hereditary spastic paraplegia type 15",
      "spastic paraplegia and retinal degeneration",
      "spastic paraplegia-retinal degeneration syndrome",
      "recessive spastic paraplegia with retinal degeneration",
      "spastic paraplegia 15",
      "spastic paraplegia 15, autosomal recessive",
      "spastic paraplegia and retinal Degeneration"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Autosomal recessive spastic paraplegia type 15 is a complex form of hereditary spastic paraplegia characterized by a childhood to adulthood onset of slowly progressive lower limb spasticity (resulting in gait disturbance, extensor plantar responses and decreased vibration sense) associated with mild intellectual disability, mild cerebellar ataxia, peripheral neuropathy (with distal upper limb amyotrophy) and retinal degeneration. Thin corpus callosum is a common imaging finding."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16082,
      "label": "complex hereditary spastic paraplegia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        18959
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019823",
          "MEDGEN:581446",
          "NANDO:1200054",
          "Orphanet:102013",
          "SCTID:230261006",
          "UMLS:C0393556"
        ],
        "synonyms": [
          "Complex HSP",
          "Complex SPG",
          "Complex familial spastic paraplegia",
          "complicated HSP",
          "complicated SPG",
          "complicated familial spastic paraplegia",
          "complicated hereditary spastic paraplegia",
          "syndrome associated with hereditary spastic paraplegia",
          "syndromic hereditary spastic paraplegia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hereditary spastic paraplegia that is part of a larger syndrome."
      },
      "child_count": 100,
      "reference_id": "MONDO:0015150"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16082,
      "label": "complex hereditary spastic paraplegia"
    }
  ]
}