{
  "id": 11321,
  "label": "thyrotoxicosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010138",
  "properties": {
    "xrefs": [
      "DOID:7997",
      "EFO:0009190",
      "ICD10CM:E05",
      "ICD9:242",
      "ICD9:242.80",
      "ICD9:242.90",
      "MEDGEN:11814",
      "MESH:D013971",
      "NCIT:C61469",
      "SCTID:90739004",
      "UMLS:C0040156",
      "icd11.foundation:1470387017"
    ],
    "synonyms": [
      "GRD1",
      "Graves disease, susceptibility to, 1"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6233,
      "label": "hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7998",
          "EFO:0009189",
          "ICD9:242.90",
          "MEDGEN:6972",
          "MESH:D006980",
          "NANDO:2100119",
          "NANDO:2200329",
          "NCIT:C3123",
          "SCTID:34486009",
          "UMLS:C0020550"
        ],
        "synonyms": [
          "overactive thyroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004425"
    }
  ],
  "children": [
    {
      "id": 3760,
      "label": "neonatal thyrotoxicosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11321
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12573",
          "ICD9:775.3",
          "MEDGEN:510684",
          "NCIT:C114906",
          "SCTID:13795004",
          "UMLS:C0158983"
        ],
        "synonyms": [
          "infantile hyperthyroidism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hypermetabolic syndrome characterized by tachycardia, palpitations, tremor, weight loss, and moist skin that is caused by the elevation of thyroid hormone levels in the serum of the newborn infant or thyroid-axis receptor activation, most commonly due to transplacental passage of thyroid stimulating globulins."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001555"
    }
  ],
  "roots": [
    {
      "id": 6233,
      "label": "hyperthyroidism"
    }
  ]
}