{
  "id": 11322,
  "label": "isolated thyroid-stimulating hormone deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010139",
  "properties": {
    "xrefs": [
      "DOID:0070123",
      "GARD:0010129",
      "MEDGEN:78786",
      "OMIM:275100",
      "Orphanet:90674",
      "UMLS:C0271789"
    ],
    "synonyms": [
      "CHNG4",
      "hypothyroidism, congenital, nongoitrous 4",
      "hypothyroidism, congenital, nongoitrous, type 4",
      "isolated TSH deficiency",
      "isolated thyrotropin deficiency",
      "TSH deficiency",
      "congenital nongoitrous hypothyroidism 4",
      "hypothyroidism, congenital, nongoitrous, 4",
      "pituitary cretinism",
      "thyroid-stimulating hormone deficiency",
      "thyroid-stimulating hormone, deficiency of",
      "thyrotropin deficiency, isolated",
      "thyrotropin, biologically inactive"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Isolated thyroid-stimulating hormone (TSH) deficiency is a type of central congenital hypothyroidism, a permanent thyroid deficiency that is present from birth, characterized by low levels of thyroid hormones due to a deficiency in TSH synthesis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2710,
      "label": "hypothyroidism, congenital, nongoitrous",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        18613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022704",
          "OMIMPS:275200"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 18,
      "reference_id": "MONDO:0000045"
    },
    {
      "id": 16927,
      "label": "central congenital hypothyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16926
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012280",
          "MEDGEN:927869",
          "NANDO:1200390",
          "NANDO:2200332",
          "NANDO:2200340",
          "NCIT:C113144",
          "Orphanet:226298",
          "UMLS:C4302200",
          "icd11.foundation:848364569"
        ],
        "synonyms": [
          "TSH deficiency",
          "central hypothyroidism",
          "hypothalamic-pituitary hypothyroidism",
          "secondary hypothyroidism",
          "thyroid stimulating hormone deficiency",
          "thyrotropin deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Central or secondary congenital hypothyroidism is a type of permanent congenital hypothyroidism characterized by permanent thyroid hormone deficiency that is present from birth and secondary to a disorder in the thyroid-stimulating hormone (TSH) - thyrotropin-releasing hormone (TRH) system."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016410"
    },
    {
      "id": 19562,
      "label": "non-acquired pituitary hormone deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16072,
        16330
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019272",
          "MEDGEN:1842784",
          "Orphanet:95488",
          "UMLS:C5681572"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 10,
      "reference_id": "MONDO:0019824"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2710,
      "label": "hypothyroidism, congenital, nongoitrous"
    },
    {
      "id": 16927,
      "label": "central congenital hypothyroidism"
    },
    {
      "id": 19562,
      "label": "non-acquired pituitary hormone deficiency"
    }
  ]
}