{
  "id": 11323,
  "label": "isolated thyrotropin-releasing hormone deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010140",
  "properties": {
    "xrefs": [
      "GARD:0017179",
      "ICD9:253.4",
      "MEDGEN:854700",
      "NCIT:C121741",
      "OMIM:275120",
      "Orphanet:238670",
      "SCTID:10736002",
      "UMLS:C3887992"
    ],
    "synonyms": [
      "isolated TRF deficiency",
      "isolated TRH deficiency",
      "isolated TSH-releasing factor deficiency",
      "isolated prothyroliberin deficiency",
      "isolated protirelin deficiency",
      "isolated thyroliberin deficiency",
      "isolated thyrotropin-releasing factor deficiency",
      "tertiary hypothyroidism",
      "TRH deficiency",
      "hypothalamic hypothyroidism",
      "thyrotropin-releasing hormone deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Hypothyroidism due to dysfunction of the hypothalamus, assumed to result in reduced secretion of thyrotropin- releasing hormone."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16927,
      "label": "central congenital hypothyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16926
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012280",
          "MEDGEN:927869",
          "NANDO:1200390",
          "NANDO:2200332",
          "NANDO:2200340",
          "NCIT:C113144",
          "Orphanet:226298",
          "UMLS:C4302200",
          "icd11.foundation:848364569"
        ],
        "synonyms": [
          "TSH deficiency",
          "central hypothyroidism",
          "hypothalamic-pituitary hypothyroidism",
          "secondary hypothyroidism",
          "thyroid stimulating hormone deficiency",
          "thyrotropin deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Central or secondary congenital hypothyroidism is a type of permanent congenital hypothyroidism characterized by permanent thyroid hormone deficiency that is present from birth and secondary to a disorder in the thyroid-stimulating hormone (TSH) - thyrotropin-releasing hormone (TRH) system."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016410"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16927,
      "label": "central congenital hypothyroidism"
    }
  ]
}