{
  "id": 11332,
  "label": "head and neck squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010150",
  "properties": {
    "xrefs": [
      "DOID:5520",
      "EFO:0000181",
      "GARD:0008503",
      "MEDGEN:257911",
      "MESH:C535575",
      "MedDRA:10060121",
      "NCIT:C34447",
      "OMIM:275355",
      "ONCOTREE:HNSC",
      "Orphanet:67037",
      "SCTID:716659002",
      "UMLS:C1168401"
    ],
    "synonyms": [
      "HNSCC",
      "SCCHN",
      "craniocervical region squamous cell carcinoma",
      "head and neck squamous cell carcinoma",
      "squamous cell carcinoma of head and neck",
      "squamous cell carcinoma of the head and neck",
      "squamous cell carcinoma, head and neck, somatic",
      "carcinoma of the head and neck",
      "squamous cell carcinoma, head and neck"
    ],
    "definition": "A squamous cell carcinoma that arises from any of the following anatomic sites: lip and oral cavity, nasal cavity, paranasal sinuses, pharynx, larynx, and salivary glands."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 13,
  "parents": [
    {
      "id": 4185,
      "label": "head and neck carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        7266
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1542",
          "MEDGEN:854345",
          "NCIT:C35850",
          "UMLS:C3887461"
        ],
        "synonyms": [
          "carcinoma of craniocervical region",
          "carcinoma of head and neck",
          "carcinoma of neck",
          "carcinoma of the head and neck",
          "craniocervical region carcinoma",
          "head and neck carcinoma",
          "neck carcinoma",
          "carcinoma of the neck",
          "head and neck cancer"
        ],
        "definition": "A carcinoma that arises from the head and neck region. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 32,
      "reference_id": "MONDO:0002038"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    }
  ],
  "children": [
    {
      "id": 2980,
      "label": "pharyngeal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7172,
        11332,
        20516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050921",
          "EFO:1001965",
          "GARD:0022794",
          "MEDGEN:728086",
          "NCIT:C102872",
          "SCTID:408649007",
          "UMLS:C1319317"
        ],
        "synonyms": [
          "pharyngeal (including hypopharyngeal and oropharyngeal) squamous cell carcinoma",
          "pharyngeal squam. cell carcinoma",
          "pharyngeal squamous cell carcinoma",
          "pharyngeal throat squamous cell cancer",
          "pharynx squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the pharynx."
      },
      "child_count": 6,
      "reference_id": "MONDO:0000536"
    },
    {
      "id": 3926,
      "label": "cornea squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        5677,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13538",
          "GARD:0022999",
          "MEDGEN:91102",
          "NCIT:C4552",
          "SCTID:255008003",
          "UMLS:C0346366"
        ],
        "synonyms": [
          "cornea epidermoid carcinoma",
          "cornea squamous cell carcinoma",
          "corneal epidermoid carcinoma",
          "corneal squamous cell carcinoma",
          "epidermoid carcinoma of cornea",
          "epidermoid carcinoma of the cornea",
          "squamous cell carcinoma of cornea",
          "squamous cell carcinoma of the cornea"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare squamous cell carcinoma that arises from the cornea."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001740"
    },
    {
      "id": 5408,
      "label": "lacrimal gland squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4543,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5529",
          "GARD:0023527",
          "MEDGEN:233607",
          "NCIT:C6092",
          "UMLS:C1334360"
        ],
        "synonyms": [
          "epidermoid carcinoma of lacrimal gland",
          "lacrimal gland epidermoid carcinoma",
          "lacrimal gland squamous cell carcinoma",
          "squamous cell carcinoma of lacrimal gland",
          "squamous cell carcinoma of the lacrimal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A squamous cell carcinoma that involves the lacrimal gland."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003492"
    },
    {
      "id": 5415,
      "label": "external ear squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4949,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5538",
          "GARD:0023531",
          "MEDGEN:232478",
          "NCIT:C6083",
          "UMLS:C1333494"
        ],
        "synonyms": [
          "epidermoid carcinoma of external Ear",
          "epidermoid carcinoma of the external Ear",
          "epidermoid carcinoma of the external ear",
          "external Ear epidermoid carcinoma",
          "external Ear squamous cell carcinoma",
          "external ear squamous cell carcinoma",
          "squamous cell carcinoma of external Ear",
          "squamous cell carcinoma of the external Ear"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the skin of the external ear."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003501"
    },
    {
      "id": 7239,
      "label": "laryngeal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4457,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2876",
          "EFO:0006352",
          "GARD:0017908",
          "MEDGEN:83630",
          "NCIT:C4044",
          "ONCOTREE:LXSC",
          "Orphanet:494550",
          "SCTID:405822008",
          "UMLS:C0280324"
        ],
        "synonyms": [
          "epidermoid carcinoma of larynx",
          "epidermoid carcinoma of the larynx",
          "laryngeal epidermoid carcinoma",
          "laryngeal squamous cell carcinoma",
          "laryngeal throat squamous cell cancer",
          "larynx epidermoid carcinoma",
          "larynx squamous cell carcinoma",
          "squamous cell carcinoma of larynx",
          "squamous cell carcinoma of the larynx",
          "LXSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the larynx. It is the most common histologic type of laryngeal carcinoma. It can arise from the glottis, supraglottic area, or it can be transglottic. Glottic squamous cell carcinoma is the most frequent laryngeal carcinoma in the United States. The symptoms, clinical behavior and the prognosis depend on the site of origin within the larynx."
      },
      "child_count": 8,
      "reference_id": "MONDO:0005595"
    },
    {
      "id": 7642,
      "label": "nasal cavity squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5168,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5515",
          "EFO:1000057",
          "GARD:0024278",
          "MEDGEN:79104",
          "NCIT:C8192",
          "UMLS:C0280333"
        ],
        "synonyms": [
          "nasal cavity squamous cell carcinoma",
          "squamous cell carcinoma of nasal cavity",
          "squamous cell carcinoma of the nasal cavity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the nasal cavity mucosa. Signs and symptoms include nasal fullness and obstruction, pain, epistaxis, and the presence of a nasal mass."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006059"
    },
    {
      "id": 7643,
      "label": "nasopharyngeal squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000058",
          "GARD:0024279",
          "MEDGEN:76017",
          "NCIT:C167265",
          "UMLS:C0279698"
        ],
        "definition": "A squamous cell carcinoma that arises from the nasopharynx."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006060"
    },
    {
      "id": 7732,
      "label": "conjunctival squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4546,
        5378,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1748",
          "EFO:1000206",
          "GARD:0024318",
          "MEDGEN:87558",
          "NCIT:C4549",
          "SCTID:255003007",
          "UMLS:C0346359"
        ],
        "synonyms": [
          "ocular surface squamous neoplasia",
          "conjunctiva epidermoid carcinoma",
          "conjunctiva squamous cell carcinoma",
          "conjunctival epidermoid carcinoma",
          "conjunctival squamous cell cancer",
          "conjunctival squamous cell carcinoma",
          "epidermoid carcinoma of conjunctiva",
          "epidermoid carcinoma of the conjunctiva",
          "squamous cell carcinoma of conjunctiva",
          "squamous cell carcinoma of the conjunctiva"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A low-grade squamous cell carcinoma that arises from the conjunctiva. It is the most common primary malignant tumor that arises from the conjunctiva. It usually affects older white males. Excessive exposure to sunlight is a risk factor. Patients may present with a mass, red eye, or pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006173"
    },
    {
      "id": 7842,
      "label": "middle ear squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5149,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5526",
          "EFO:1000378",
          "GARD:0024367",
          "MEDGEN:233191",
          "NCIT:C6086",
          "UMLS:C1334762"
        ],
        "synonyms": [
          "epidermoid carcinoma of middle Ear",
          "epidermoid carcinoma of the middle Ear",
          "epidermoid carcinoma of the middle ear",
          "middle Ear epidermoid carcinoma",
          "middle ear squamous cell carcinoma",
          "squamous cell carcinoma of middle Ear",
          "squamous cell carcinoma of the middle Ear"
        ],
        "categories": [
          {
            "ref": "MONDO:0002409",
            "name": "auditory system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare squamous cell carcinoma that arises from the middle ear."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006303"
    },
    {
      "id": 7905,
      "label": "primary intraosseous squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000492",
          "GARD:0024390",
          "MEDGEN:313618",
          "NCIT:C54295",
          "UMLS:C1709663"
        ],
        "synonyms": [
          "PIOSCC"
        ],
        "definition": "A squamous cell carcinoma that arises centrally from the jaw. It derives from odontogenic epithelial remnants. It includes solid type squamous cell carcinoma, squamous cell carcinoma that arises from an odontogenic cyst, and squamous cell carcinoma that derives from a keratocystic odontogenic tumor."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006385"
    },
    {
      "id": 23399,
      "label": "paranasal sinus squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2879,
        2965,
        11332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2442",
          "GARD:0017927",
          "MEDGEN:79105",
          "NCIT:C8193",
          "Orphanet:500464",
          "UMLS:C0280334"
        ],
        "synonyms": [
          "epidermoid carcinoma of paranasal sinus",
          "epidermoid carcinoma of the paranasal sinus",
          "paranasal sinus epidermoid carcinoma",
          "paranasal sinus squamous cell carcinoma",
          "squamous cell carcinoma of paranasal sinus",
          "squamous cell carcinoma of the nasal cavity and sinuses",
          "squamous cell carcinoma of the paranasal sinus",
          "squamous cell carcinoma of the nasal cavity and paranasal sinuses"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma that arises from the mucosal epithelial surface of the ethmoid, frontal, maxillary, or sphenoid sinus. Patients may present with nasal fullness, obstruction, and/or epistaxis."
      },
      "child_count": 12,
      "reference_id": "MONDO:0044705"
    },
    {
      "id": 23401,
      "label": "lip and oral cavity squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11332,
        21254,
        21538
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022046",
          "MEDGEN:124714",
          "NCIT:C42690",
          "Orphanet:502369",
          "UMLS:C0280297"
        ],
        "synonyms": [
          "lip and oral cavity squamous cell cancer",
          "lip and oral cavity squamous cell carcinoma",
          "lip/oral cavity squam. cell car.",
          "squamous cell carcinoma of oral cavity and lip"
        ],
        "categories": [
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes."
      },
      "child_count": 3,
      "reference_id": "MONDO:0044710"
    },
    {
      "id": 23441,
      "label": "nasal cavity and paranasal sinus squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11332,
        23674
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025910",
          "MEDGEN:124722",
          "NCIT:C68611",
          "UMLS:C0280332"
        ],
        "synonyms": [
          "nasal cavity and paranasal sinus squamous cell cancer",
          "nasal cavity and paranasal sinus squamous cell carcinoma"
        ],
        "definition": "A rare, keratinizing or non-keratinizing squamous cell carcinoma arising from the mucosal epithelium of the nasal cavity or the paranasal sinuses. It affects most often the maxillary sinus. Less frequently, it arises from the nasal cavity, ethmoid sinus, sphenoid sinus, and frontal sinus. Symptoms include nasal fullness, epistaxis, rhinorhea, pain, and paresthesia. Patients with nasal squamous cell carcinoma usually present earlier than patients with maxillary sinus carcinoma and have a better prognosis compared to the latter group."
      },
      "child_count": 2,
      "reference_id": "MONDO:0044787"
    }
  ],
  "roots": [
    {
      "id": 4185,
      "label": "head and neck carcinoma"
    },
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    }
  ]
}