{
  "id": 11753,
  "label": "hemophilia B",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010604",
  "properties": {
    "xrefs": [
      "DOID:12259",
      "GARD:0008732",
      "ICD10CM:D67",
      "ICD9:286.1",
      "MEDGEN:945",
      "MESH:D002836",
      "MedDRA:10016077",
      "NANDO:2200677",
      "NCIT:C26721",
      "NORD:1222",
      "OMIM:306900",
      "Orphanet:98879",
      "SCTID:41788008",
      "UMLS:C0008533",
      "icd11.foundation:1901375668"
    ],
    "synonyms": [
      "Christmas disease",
      "congenital factor IX deficiency",
      "congenital factor IX disorder",
      "factor IX deficiency",
      "haemophilia b, X-linked recessive",
      "haemophilia type B",
      "hemophilia B",
      "hemophilia b, X-linked recessive",
      "hemophilia type B",
      "hereditary Factor IX deficiency",
      "hereditary Factor IX deficiency disease",
      "F9 deficiency",
      "HEMB",
      "factor 9 deficiency",
      "haemophilia B Leyden",
      "haemophilia B(M)",
      "hem B",
      "hemophilia B Leyden",
      "hemophilia B(M)",
      "plasma thromboplastin component deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Hemophilia B is a form of hemophilia characterized by spontaneous or prolonged hemorrhages due to factor IX deficiency."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4360,
      "label": "hemorrhagic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2213",
          "ICD9:287.9",
          "MEDGEN:6799",
          "MESH:D006474",
          "NCIT:C115221",
          "UMLS:C0019087"
        ],
        "synonyms": [
          "bleeding diathesis",
          "bleeding disorder",
          "bleeding predisposition",
          "bleeding tendency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders)."
      },
      "child_count": 28,
      "reference_id": "MONDO:0002243"
    },
    {
      "id": 18652,
      "label": "hemophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4359
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0061030",
          "GARD:0010418",
          "MEDGEN:146334",
          "MedDRA:10061992",
          "NCIT:C3093",
          "Orphanet:448",
          "SCTID:90935002",
          "UMLS:C0684275"
        ],
        "synonyms": [
          "hemophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemophilia is a genetic disorder characterized by spontaneous hemorrhage or prolonged bleeding due to factor VIII or IX deficiency."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018660"
    },
    {
      "id": 20411,
      "label": "inherited blood coagulation disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3738,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2214",
          "GARD:0020319",
          "MEDGEN:163105",
          "MESH:D025861",
          "Orphanet:183654",
          "UMLS:C0852077"
        ],
        "synonyms": [
          "coagulation disorder, hereditary",
          "coagulation disorder, inherited",
          "coagulation disorders, hereditary",
          "coagulation disorders, inherited",
          "hereditary blood coagulation disease",
          "hereditary blood coagulation disorders",
          "hereditary coagulation disorder",
          "hereditary coagulation disorders",
          "inherited blood coagulation disorders",
          "inherited coagulation disorder",
          "inherited coagulation disorders",
          "rare genetic coagulation disorder",
          "inherited blood coagulation disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation."
      },
      "child_count": 78,
      "reference_id": "MONDO:0021181"
    }
  ],
  "children": [
    {
      "id": 16475,
      "label": "severe hemophilia B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017056",
          "MEDGEN:1826004",
          "Orphanet:169793",
          "UMLS:C5679576"
        ],
        "synonyms": [
          "severe factor IX deficiency",
          "severe haemophilia type B",
          "severe hemophilia type B"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Severe hemophilia B is a form of hemophilia B characterized by a large deficiency of factor IX leading to frequent spontaneous hemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015715"
    },
    {
      "id": 16476,
      "label": "moderately severe hemophilia B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017057",
          "MEDGEN:1842225",
          "Orphanet:169796",
          "UMLS:C5679575"
        ],
        "synonyms": [
          "moderately severe factor IX deficiency",
          "moderately severe haemophilia type B",
          "moderately severe hemophilia type B"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Moderately severe hemophilia B is a form of hemophilia B characterized by factor IX deficiency leading to abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015716"
    },
    {
      "id": 16477,
      "label": "mild hemophilia B",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017058",
          "MEDGEN:1826003",
          "Orphanet:169799",
          "UMLS:C5679574"
        ],
        "synonyms": [
          "mild factor IX deficiency",
          "mild haemophilia type B",
          "mild hemophilia type B"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Mild hemophilia B is a form of hemophilia B characterized by a small deficiency of factor IX leading to abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015717"
    },
    {
      "id": 16542,
      "label": "symptomatic form of hemophilia B in female carriers",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11753
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017077",
          "MEDGEN:1843014",
          "Orphanet:177929",
          "UMLS:C5680505"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A form of hemophilia B (see this term) that manifests in some women with mutations in the F9 gene (Xq28), encoding coagulation factor IX."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015788"
    }
  ],
  "roots": [
    {
      "id": 4360,
      "label": "hemorrhagic disease"
    },
    {
      "id": 18652,
      "label": "hemophilia"
    },
    {
      "id": 20411,
      "label": "inherited blood coagulation disorder"
    }
  ]
}