{
  "id": 11789,
  "label": "acute leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010643",
  "properties": {
    "xrefs": [
      "DOID:12603",
      "EFO:1000068",
      "GARD:0024743",
      "HP:0002488",
      "ICD9:208.0",
      "ICD9:208.00",
      "ICDO:9801/3",
      "MEDGEN:43225",
      "MESH:C564112",
      "NCIT:C9300",
      "SCTID:91855006",
      "UMLS:C0085669"
    ],
    "synonyms": [
      "acute leukaemia (disease)",
      "acute leukemia",
      "acute leukemia (disease)",
      "leukemia, acute, X-linked",
      "stem cell leukaemia",
      "stem cell leukaemia (disease)",
      "stem cell leukemia",
      "stem cell leukemia (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6789,
      "label": "leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1240",
          "EFO:0000565",
          "HP:0001909",
          "ICD9:207",
          "ICD9:207.8",
          "ICD9:207.80",
          "ICD9:208",
          "ICD9:208.8",
          "ICD9:208.80",
          "ICD9:208.9",
          "ICD9:208.90",
          "ICDO:9800/3",
          "MEDGEN:9725",
          "MESH:D007938",
          "NANDO:2100002",
          "NCIT:C3161",
          "SCTID:93143009",
          "UMLS:C0023418"
        ],
        "synonyms": [
          "blood (leukemia)",
          "leukaemia (disease)",
          "leukemia",
          "leukemia (disease)",
          "leukemia, disease",
          "leukemia, malignant",
          "leukemias",
          "leukemias, general",
          "leukaemia NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005059"
    },
    {
      "id": 20092,
      "label": "acute disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24492
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:799.89",
          "MEDGEN:1738",
          "MESH:D000208",
          "SCTID:2704003",
          "UMLS:C0001314"
        ],
        "synonyms": [
          "acute disease",
          "acute diseases",
          "disease, acute"
        ],
        "definition": "Disease having a short and relatively severe course."
      },
      "child_count": 119,
      "reference_id": "MONDO:0020683"
    }
  ],
  "children": [
    {
      "id": 4643,
      "label": "subacute leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3264",
          "GARD:0023176",
          "ICD9:208.2",
          "ICD9:208.20",
          "MEDGEN:509481",
          "SCTID:302855005",
          "UMLS:C0153924"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002582"
    },
    {
      "id": 6710,
      "label": "acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5444,
        6890,
        7079,
        11789,
        18836
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9952",
          "EFO:0000220",
          "GARD:0000522",
          "HP:0006721",
          "ICD10CM:C91.0",
          "ICD9:204",
          "ICD9:204.0",
          "ICD9:204.00",
          "ICD9:204.9",
          "ICDO:9835/3",
          "MEDGEN:7317",
          "NCIT:C3167",
          "Orphanet:513",
          "SCTID:91857003",
          "UMLS:C0023449"
        ],
        "synonyms": [
          "lymphoblastic leukaemia",
          "lymphoblastic leukemia",
          "ALL",
          "ALL - acute lymphocytic leukaemia",
          "ALL - acute lymphocytic leukemia",
          "acute lymphoblastic leukaemia (ALL)",
          "acute lymphoblastic leukaemia (disease)",
          "acute lymphoblastic leukemia",
          "acute lymphoblastic leukemia (ALL)",
          "acute lymphoblastic leukemia (disease)",
          "acute lymphoblastic leukemia/lymphoma",
          "acute lymphocytic leukaemia",
          "acute lymphocytic leukemia",
          "acute lymphocytic leukemias",
          "acute lymphogenous leukaemia",
          "acute lymphogenous leukemia",
          "acute lymphoid leukaemia",
          "acute lymphoid leukemia",
          "leukemia, lymphoblastic, malignant",
          "lymphoblastic leukemia, acute",
          "precursor Lymphoblasic leukaemia",
          "precursor Lymphoblasic leukemia",
          "precursor cell lymphoblastic leukaemia",
          "precursor cell lymphoblastic leukemia",
          "precursor lymphoblastic leukaemia",
          "precursor lymphoblastic leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia."
      },
      "child_count": 60,
      "reference_id": "MONDO:0004967"
    },
    {
      "id": 18806,
      "label": "acute myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9119",
          "EFO:0000222",
          "GARD:0012757",
          "ICD10CM:C92.0",
          "ICD9:205.0",
          "ICD9:205.00",
          "ICDO:9861/3",
          "MEDGEN:9730",
          "MESH:D015470",
          "MedDRA:10000880",
          "NCIT:C3171",
          "NORD:1905",
          "OMIM:601626",
          "ONCOTREE:AML",
          "Orphanet:519",
          "SCTID:91861009",
          "UMLS:C0023467"
        ],
        "synonyms": [
          "AML",
          "AML - acute myeloid leukaemia",
          "AML - acute myeloid leukemia",
          "ANLL",
          "acute Nonlymphocytic leukaemia",
          "acute Nonlymphocytic leukemia",
          "acute granulocytic leukaemia",
          "acute granulocytic leukemia",
          "acute myeloblastic leukemia",
          "acute myelocytic leukaemia",
          "acute myelocytic leukemia",
          "acute myelogenous leukemia",
          "acute myelogenous leukemias",
          "acute myeloid leukaemia (AML)",
          "acute myeloid leukemia",
          "acute myeloid leukemia (AML)",
          "acute myeloid leukemia, somatic",
          "acute nonlymphocytic leukaemia",
          "acute nonlymphocytic leukemia",
          "hematopoeitic - acute Myleogenous leukaemia (AML)",
          "hematopoeitic - acute Myleogenous leukemia (AML)",
          "leukemia, acute myeloid, autosomal dominant, somatic mutation",
          "leukemia, acute myeloid, reduced survival in, somatic",
          "leukemia, acute myeloid, somatic",
          "leukemia, acute myeloid, susceptibility to, autosomal dominant, somatic mutation",
          "leukemia, myelocytic, acute",
          "myeloid leukemia, acute",
          "myeloid leukemia, acute, M4/M4Eo subtype, somatic",
          "acute non lymphoblastic leukaemia",
          "acute non lymphoblastic leukemia",
          "leukemia, acute myelogenous",
          "leukemia, acute myeloid",
          "leukemia, acute myeloid, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute myeloid leukemia (AML) is a group of neoplasms arising from precursor cells committed to the myeloid cell-line differentiation. All of them are characterized by clonal expansion of myeloid blasts. AML manifests by fever, pallor, anemia, hemorrhages and recurrent infections."
      },
      "child_count": 156,
      "reference_id": "MONDO:0018874"
    },
    {
      "id": 24456,
      "label": "leukemia, acute, X-linked",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2902,
        11789
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026337",
          "MEDGEN:502257",
          "OMIM:308960",
          "UMLS:C3501854"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "X-linked form of acute leukemia"
      },
      "child_count": 0,
      "reference_id": "MONDO:0700060"
    }
  ],
  "roots": [
    {
      "id": 6789,
      "label": "leukemia"
    },
    {
      "id": 20092,
      "label": "acute disease"
    }
  ]
}