{
  "id": 11906,
  "label": "gonadoblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010768",
  "properties": {
    "xrefs": [
      "DOID:3301",
      "ICDO:9073/1",
      "MEDGEN:104912",
      "MESH:D018238",
      "NCIT:C3754",
      "ONCOTREE:OGBL",
      "UMLS:C0206661"
    ],
    "synonyms": [
      "gonad blastoma",
      "gonadoblastoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A mixed germ cell/sex cord-stromal tumor characterized by the presence of large germ cells which resemble seminoma cells and small cells which resemble Sertoli or granulosa cells. It occurs in the testis and the ovary and is identified in children and adults. It is often associated with gonadal dysgenesis and abnormal karyotype."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4279,
      "label": "reproductive system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:193",
          "MEDGEN:233668",
          "NCIT:C36076",
          "UMLS:C1334618"
        ],
        "synonyms": [
          "reproductive tumor",
          "reproductive tumour",
          "cancer of reproductive organ",
          "cancer of reproductive system",
          "malignant neoplasm of reproductive organ",
          "malignant neoplasm of reproductive system",
          "malignant reproductive organ neoplasm",
          "malignant reproductive system neoplasm",
          "reproductive organ cancer",
          "reproductive system cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the reproductive organ"
      },
      "child_count": 16,
      "reference_id": "MONDO:0002149"
    },
    {
      "id": 4375,
      "label": "gonadal disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6772,
        6875
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2277",
          "MEDGEN:9074",
          "MESH:D006058",
          "NCIT:C26786",
          "UMLS:C0018050"
        ],
        "synonyms": [
          "disease of gonad",
          "disease or disorder of gonad",
          "disorder of gonad",
          "disorder of gonads",
          "gonad disease",
          "gonad disease or disorder",
          "gonadal disorder",
          "gonadal disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-neoplastic or neoplastic disorder that affects the testis or the ovary."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002259"
    },
    {
      "id": 4558,
      "label": "mixed germ cell-sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2996",
          "MEDGEN:232941",
          "NCIT:C5241",
          "UMLS:C1321220"
        ],
        "synonyms": [
          "mixed germ cell-Sex cord neoplasm",
          "mixed germ cell-Sex cord tumor",
          "mixed germ cell-Sex cord tumour",
          "mixed germ cell-Sex cord-stromal neoplasm",
          "mixed germ cell-Sex cord-stromal tumor",
          "mixed germ cell-Sex cord-stromal tumour",
          "mixed germ cell-sex cord-stromal tumor (morphologic abnormality)",
          "mixed germ cell-sex cord-stromal tumour (morphologic abnormality)"
        ],
        "definition": "A biphasic neoplasm that arises from the ovary or the testis. It is characterized by the presence of neoplastic germ cells and neoplastic sex cord-stromal cells. It includes the gonadoblastoma and mixed germ cell-sex cord stromal tumor, unclassifiable."
      },
      "child_count": 1,
      "reference_id": "MONDO:0002478"
    },
    {
      "id": 7213,
      "label": "blastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7212
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0070003",
          "DOID:4766",
          "EFO:0005785",
          "ICDO:8981/3",
          "MEDGEN:181704",
          "NCIT:C8997",
          "UMLS:C0936282"
        ],
        "synonyms": [
          "blastoma",
          "embryoma"
        ],
        "definition": "A malignant neoplasm composed of undifferentiated cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0005565"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20288
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:154",
          "EFO:1000356",
          "ICDO:8940/3",
          "MEDGEN:64618",
          "MESH:D018198",
          "NCIT:C3729",
          "UMLS:C0206625"
        ],
        "synonyms": [
          "mixed cell type cancer",
          "mixed neoplasm",
          "mixed tumor",
          "mixed tumour",
          "malignant mixed neoplasm",
          "malignant mixed tumor",
          "malignant mixed tumour",
          "mixed neoplasm, malignant",
          "mixed tumor, malignant (morphologic abnormality)",
          "mixed tumor, malignant, NOS (morphologic abnormality)",
          "tumor, mixed, malignant",
          "malignant mixed tumors",
          "malignant mixed tumours",
          "mixed tumors, malignant",
          "tumor, malignant mixed",
          "tumors, malignant mixed"
        ],
        "definition": "A malignant neoplasm composed of a carcinomatous epithelial component and a sarcomatous mesenchymal component. Representative examples include malignant mixed mesodermal (Mullerian) tumor of the female reproductive system and carcinosarcoma of the salivary gland and the lung."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005853"
    },
    {
      "id": 7639,
      "label": "sex cord-stromal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7638
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:192",
          "EFO:1000052",
          "ICDO:8590/1",
          "MEDGEN:104926",
          "NANDO:2200072",
          "NCIT:C3794",
          "UMLS:C0206724"
        ],
        "synonyms": [
          "Sex cord stromal tumor",
          "Sex cord-stromal neoplasm",
          "Sex cord-stromal tumor",
          "Sex cord-stromal tumor, no ICD-O subtype",
          "Sex cord-stromal tumor, no ICD-O subtype (morphologic abnormality)",
          "Sex cord-stromal tumour",
          "neoplasm of sex cord",
          "sex cord neoplasm",
          "sex cord tumor",
          "sex cord tumour",
          "sex cord-stromal tumor",
          "specialised gonadal neoplasm",
          "specialised gonadal neoplasm (morphologic abnormality)",
          "specialised gonadal neoplasm NOS (morphologic abnormality)",
          "specialised gonadal tumour",
          "specialised gonadal tumour (qualifier value)",
          "specialized gonadal neoplasm (morphologic abnormality)",
          "specialized gonadal neoplasm NOS (morphologic abnormality)",
          "specialized gonadal tumor (qualifier value)",
          "tumor of sex cord",
          "tumour of sex cord",
          "malignant testicular sex cord-stromal tumor",
          "malignant testicular sex cord-stromal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A neoplasm involving a sex cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0006055"
    }
  ],
  "children": [
    {
      "id": 4741,
      "label": "ovarian gonadoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        11906,
        18316
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3578",
          "GARD:0017100",
          "HP:0000149",
          "MEDGEN:309510",
          "NCIT:C39985",
          "OMIM:424500",
          "Orphanet:206484",
          "SCTID:716594002",
          "UMLS:C1518716",
          "icd11.foundation:1564602847"
        ],
        "synonyms": [
          "GBY",
          "gonadoblastoma",
          "gonadoblastoma of ovary",
          "ovarian gonadoblastoma",
          "ovarian gonadoblastoma (disease)",
          "ovary gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm that arises from the ovary and is composed of tissues that resemble dysgerminoma or seminoma and are admixed with sex cord tissues. It is found in children or young adults and usually is associated with secondary sex organs abnormalities. The majority of patients present as phenotypic females with virilization. The minority of patients present as phenotypic males with feminization. It typically affects both gonads. If a malignant germ cell component is present, it may metastasize to other anatomic sites."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002697"
    },
    {
      "id": 4742,
      "label": "testicular gonadoblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5102,
        7111,
        11906
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3579",
          "GARD:0023215",
          "HP:0000030",
          "MEDGEN:272839",
          "NCIT:C39911",
          "UMLS:C1515283"
        ],
        "synonyms": [
          "gonadoblastoma of testis",
          "testicular gonadoblastoma",
          "testicular gonadoblastoma (disease)",
          "testis gonadoblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A testicular mixed germ cell-sex cord-stromal tumor. It is usually associated with mixed gonadal dysgenesis and ambiguous genitalia. It is characterized by the presence of nests of large neoplastic germ cells and immature cells that resemble Sertoli cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0002698"
    }
  ],
  "roots": [
    {
      "id": 4279,
      "label": "reproductive system cancer"
    },
    {
      "id": 4375,
      "label": "gonadal disorder"
    },
    {
      "id": 4558,
      "label": "mixed germ cell-sex cord-stromal tumor"
    },
    {
      "id": 7213,
      "label": "blastoma"
    },
    {
      "id": 7464,
      "label": "malignant mixed neoplasm"
    },
    {
      "id": 7639,
      "label": "sex cord-stromal tumor"
    }
  ]
}