{
  "id": 11945,
  "label": "familial chronic myelocytic leukemia-like syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010809",
  "properties": {
    "xrefs": [
      "DOID:0060761",
      "GARD:0010141",
      "MEDGEN:325075",
      "MESH:C536093",
      "OMIM:600080",
      "UMLS:C1838670"
    ],
    "synonyms": [
      "CML-like syndrome, familial",
      "myelocytic leukemia-like syndrome, familial, chronic"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A chronic myeloid leukemia characterized by chronic myelocytic leukemia in early infancy and absence of the BCR/ABL fusion gene (Philadelphia chromosome)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6429,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081088",
          "DOID:8552",
          "EFO:0000339",
          "GARD:0006105",
          "ICD9:205.1",
          "ICDO:9863/3",
          "ICDO:9875/3",
          "MEDGEN:75993",
          "MedDRA:10009013",
          "NANDO:2200013",
          "NCIT:C3174",
          "OMIM:608232",
          "ONCOTREE:CML",
          "Orphanet:521",
          "UMLS:C0279543"
        ],
        "synonyms": [
          "BCR-ABL Positive chronic myelogenous leukaemia",
          "BCR-ABL Positive chronic myelogenous leukemia",
          "CML",
          "CML - chronic myelogenous leukaemia",
          "CML - chronic myelogenous leukemia",
          "chronic granulocytic leukemia",
          "chronic myelocytic leukaemia",
          "chronic myelocytic leukemia",
          "chronic myelogenous leukaemia (CML)",
          "chronic myelogenous leukemia",
          "chronic myelogenous leukemia (CML)",
          "chronic myelogenous leukemia, BCR-ABL1 Positive",
          "chronic myelogenous leukemias",
          "chronic myeloid leukemia",
          "hematopoeitic - chronic myelocytic leukaemia (CML)",
          "hematopoeitic - chronic myelocytic leukemia (CML)",
          "leukemia, Philadelphia chromosome-positive, resistant to imatinib, Somatic mutation",
          "leukemia, chronic myeloid, Philadelphia chromosome positive, somatic",
          "myeloid leukemia, chronic",
          "leukemia, chronic myelogenous",
          "leukemia, chronic myeloid",
          "leukemia, chronic myeloid, atypical"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival."
      },
      "child_count": 6,
      "reference_id": "MONDO:0011996"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 13067,
      "label": "chronic myelogenous leukemia, BCR-ABL1 positive"
    }
  ]
}