{
  "id": 11956,
  "label": "autosomal recessive juvenile Parkinson disease 2",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010820",
  "properties": {
    "xrefs": [
      "DOID:0060368",
      "GARD:0009642",
      "MEDGEN:401500",
      "OMIM:600116",
      "UMLS:C1868675"
    ],
    "synonyms": [
      "PRKN young-onset Parkinson disease",
      "Parkinson disease, juvenile, type 2",
      "autosomal recessive juvenile Parkinson disease 2",
      "autosomal recessive juvenile Parkinson disease type 2",
      "young-onset Parkinson disease caused by mutation in PRKN",
      "JP",
      "PARK2",
      "PDJ",
      "Parkinson disease 2",
      "Parkinson disease 2, autosomal recessive juvenile",
      "Parkinson disease autosomal recessive, early onset",
      "Parkinson disease, juvenile, autosomal recessive",
      "Parkinsonism, early onset, with diurnal fluctuation",
      "Parkinsonism, early-onset, with diurnal fluctuation",
      "autosomal recessive juvenile Parkinson disease",
      "autosomal recessive juvenile Parkinson's disease 2",
      "juvenile parkinsonism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A group of disorders which feature impaired motor control characterized by bradykinesia, muscle rigidity; tremor; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see Parkinson disease), secondary parkinsonism (see Parkinson disease, secondary) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the basal ganglia."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17603,
      "label": "young-onset Parkinson disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6901
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060894",
          "GARD:0016610",
          "MEDGEN:907947",
          "Orphanet:2828",
          "SCTID:715345007",
          "UMLS:C4275179"
        ],
        "synonyms": [
          "YOPD",
          "early-onset Parkinson disease",
          "early-onset Parkinson's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017279"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17603,
      "label": "young-onset Parkinson disease"
    }
  ]
}