{
  "id": 11973,
  "label": "primary hyperparathyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010837",
  "properties": {
    "xrefs": [
      "DOID:11202",
      "EFO:0008519",
      "HP:0008200",
      "ICD10CM:E21.0",
      "ICD9:252.01",
      "MEDGEN:66354",
      "MESH:D049950",
      "NCIT:C48280",
      "SCTID:36348003",
      "UMLS:C0221002",
      "icd11.foundation:817194045"
    ],
    "synonyms": [
      "primary hyperparathyroidism",
      "primary hyperparathyroidism (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 3927,
      "label": "hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3463
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13543",
          "EFO:0008506",
          "ICD9:252.0",
          "ICD9:252.00",
          "MEDGEN:6967",
          "MESH:D006961",
          "NANDO:2100123",
          "NANDO:2200343",
          "NCIT:C48259",
          "SCTID:66999008",
          "UMLS:C0020502",
          "icd11.foundation:9633776"
        ],
        "synonyms": [
          "hyperparathyroidism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001741"
    }
  ],
  "children": [
    {
      "id": 16897,
      "label": "familial primary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11973,
        16765,
        20525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002837",
          "MEDGEN:543605",
          "Orphanet:2207",
          "UMLS:C0271846",
          "icd11.foundation:1186866066"
        ],
        "synonyms": [
          "hereditary primary hyperparathyroidism (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of primary hyperparathyroidism (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 15,
      "reference_id": "MONDO:0016365"
    }
  ],
  "roots": [
    {
      "id": 3927,
      "label": "hyperparathyroidism"
    }
  ]
}