{
  "id": 12090,
  "label": "obesity due to prohormone convertase I deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0010961",
  "properties": {
    "xrefs": [
      "DOID:0111698",
      "GARD:0016689",
      "MEDGEN:318777",
      "MESH:C563423",
      "NORD:109523",
      "OMIM:600955",
      "Orphanet:71528",
      "SCTID:722053001",
      "UMLS:C1833053"
    ],
    "synonyms": [
      "PCI deficiency",
      "PCSK1 Deficiency",
      "obesity and endocrinopathy due to impaired processing of prohormones",
      "proprotein convertase 1/3 deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Prohormone convertase-I deficiency is the rarest form of monogenic obesity. The disorder is characterized by severe childhood obesity, hypoadrenalism, reactive hypoglycaemia, and elevated circulating levels of certain prohormones."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16526,
      "label": "congenital hypogonadotropic hypogonadism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18569,
        19562
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020135",
          "MEDGEN:859097",
          "NANDO:1200383",
          "NCIT:C120162",
          "Orphanet:174590",
          "SCTID:722944006",
          "UMLS:C3899503",
          "icd11.foundation:1752075408"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder of sexual maturation characterized by gonadotropin (Gn) deficiency with low sex steroid levels associated with low levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH)."
      },
      "child_count": 50,
      "reference_id": "MONDO:0015770"
    },
    {
      "id": 19055,
      "label": "inherited obesity",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6875,
        12246
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018935",
          "MEDGEN:885912",
          "OMIM:601665",
          "Orphanet:77828",
          "UMLS:C4054476"
        ],
        "synonyms": [
          "genetic obesity",
          "genetic obesity (disease)",
          "leanness, inherited, autosomal recessive",
          "monogenic obesity",
          "obesity, association with, Autosomal recessive",
          "obesity, early-onset, susceptibility to, Autosomal recessive",
          "obesity, late-onset, Autosomal recessive",
          "obesity, mild, early-onset, Autosomal recessive",
          "obesity, severe, Autosomal recessive",
          "obesity, severe, and type II diabetes, Autosomal recessive",
          "obesity, susceptibility to, Autosomal recessive"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 21,
      "reference_id": "MONDO:0019182"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16526,
      "label": "congenital hypogonadotropic hypogonadism"
    },
    {
      "id": 19055,
      "label": "inherited obesity"
    }
  ]
}