{
  "id": 12149,
  "label": "hereditary mixed polyposis syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011023",
  "properties": {
    "xrefs": [
      "DOID:0111684",
      "GARD:0016981",
      "MEDGEN:1672870",
      "MESH:C563365",
      "OMIMPS:601228",
      "Orphanet:157794",
      "UMLS:C5192681",
      "icd11.foundation:219068911"
    ],
    "synonyms": [
      "HMPS",
      "hereditary mixed polyposis syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Hereditary mixed polyposis syndrome (HMPS) describes an autosomal dominantly inherited large-bowel disease characterized by the presence of a mixture of hyperplastic, atypical juvenile and adenomatous polyps that are associated with an increased risk of developing colorectal cancer if left untreated."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6151,
      "label": "digestive system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:77",
          "ICD10CM:K00-K95",
          "ICD9:520-579",
          "ICD9:V47.3",
          "MEDGEN:892790",
          "MESH:D005767",
          "NANDO:1100013",
          "NCIT:C2990",
          "SCTID:53619000",
          "UMLS:C4023588",
          "icd11.foundation:1256772020"
        ],
        "synonyms": [
          "digestive disease",
          "digestive system disease",
          "digestive system disease or disorder",
          "digestive system disorder",
          "disease of digestive system",
          "disease or disorder of digestive system",
          "disorder of digestive system",
          "gastroenterological system disease",
          "gastroenterological system disorder",
          "gastrointestinal disorder",
          "gastrointestinal system disease",
          "gastrointestinal system disorder",
          "stomach or intestinal disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A disease or disorder that involves the digestive system."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004335"
    },
    {
      "id": 16103,
      "label": "intestinal polyposis syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16218
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019847",
          "MEDGEN:577190",
          "MedDRA:10057018",
          "NCIT:C155954",
          "Orphanet:104010",
          "SCTID:254589009",
          "UMLS:C0345891"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A syndrome associated with the development of multiple polyps throughout the intestine. It includes familial adenomatous polyposis , hamartomatous polyposis syndromes, and other rare polyposis syndromes."
      },
      "child_count": 8,
      "reference_id": "MONDO:0015185"
    }
  ],
  "children": [
    {
      "id": 13456,
      "label": "polyposis syndrome, hereditary mixed, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111686",
          "GARD:0018276",
          "MEDGEN:350500",
          "MESH:C566451",
          "OMIM:610069",
          "UMLS:C1864730"
        ],
        "synonyms": [
          "BMPR1A hereditary mixed polyposis syndrome",
          "hereditary mixed polyposis syndrome caused by mutation in BMPR1A",
          "polyposis syndrome, hereditary mixed, 2",
          "polyposis syndrome, hereditary mixed, type 2",
          "HMPS2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Any hereditary mixed polyposis syndrome in which the cause of the disease is a mutation in the BMPR1A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012405"
    },
    {
      "id": 23060,
      "label": "polyposis syndrome, hereditary mixed, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111685",
          "GARD:0025848",
          "MEDGEN:331320",
          "OMIM:601228",
          "UMLS:C1832587"
        ],
        "synonyms": [
          "polyposis syndrome, hereditary mixed 1",
          "polyposis syndrome, hereditary mixed, 1",
          "HMPS1",
          "chromosome 15Q13-q14 Duplication syndrome, 40-Kb",
          "colorectal adenoma and carcinoma 1",
          "colorectal cancer, susceptibility to, 4",
          "colorectal cancer, susceptibility to, on chromosome 15"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0042486"
    }
  ],
  "roots": [
    {
      "id": 6151,
      "label": "digestive system disorder"
    },
    {
      "id": 16103,
      "label": "intestinal polyposis syndrome"
    }
  ]
}