{
  "id": 12534,
  "label": "juvenile idiopathic arthritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011429",
  "properties": {
    "xrefs": [
      "DOID:676",
      "EFO:0002609",
      "GARD:0018677",
      "ICD9:714.3",
      "ICD9:714.31",
      "ICD9:714.33",
      "MEDGEN:760659",
      "MESH:D001171",
      "MedDRA:10059177",
      "NANDO:1200469",
      "NANDO:2200415",
      "NCIT:C114357",
      "NORD:808",
      "OMIM:604302",
      "Orphanet:92",
      "SCTID:410502007",
      "UMLS:C3495559",
      "icd11.foundation:1322678686"
    ],
    "synonyms": [
      "Arthritis, Juvenile Rheumatoid",
      "JIA",
      "Juvenile idiopathic arthritis",
      "juvenile idiopathic arthritis",
      "juvenile rheumatoid arthritis",
      "rheumatoid arthritis, systemic juvenile, susceptibility to",
      "acute juvenile rheumatoid arthritis",
      "monarticular juvenile rheumatoid arthritis",
      "pauciarticular juvenile arthritis",
      "pauciarticular onset juvenile chronic arthritis",
      "systemic juvenile rheumatoid arthritis",
      "juvenile chronic arthritis",
      "juvenile chronic polyarthritis",
      "rheumatoid arthritis, systemic juvenile"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "Juvenile idiopathic arthritis (JIA) is the term used to describe a group of inflammatory articular disorders of unknown cause that begin before the age of 16 and last over 6 weeks. The term juvenile idiopathic arthritis was chosen to signify the absence of any known mechanism underlying the disorder and to highlight the necessity of excluding other types of arthritis occurring in well defined diseases (in particular arthritis occurring in association with infectious, inflammatory and haematooncologic diseases)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7203,
      "label": "rheumatic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5762
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1575",
          "EFO:0005755",
          "ICD9:729.0",
          "MEDGEN:3157",
          "MESH:D012216",
          "NANDO:2100151",
          "NANDO:2100152",
          "NCIT:C27204",
          "SCTID:396332003",
          "UMLS:C0009326",
          "Wikipedia:Rheumatism"
        ],
        "synonyms": [
          "rheumatic disease",
          "rheumatologic disorder",
          "collagen disease",
          "collagen vascular disease",
          "connective tissue disease",
          "disease, rheumatic",
          "diseases, rheumatic",
          "enthesopathies",
          "enthesopathy",
          "inflammatory rheumatism",
          "musculoskeletal pain disorder",
          "rheumatism"
        ],
        "categories": [
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Inflammatory and degenerative diseases of connective tissue structures, such as arthritis."
      },
      "child_count": 30,
      "reference_id": "MONDO:0005554"
    },
    {
      "id": 7223,
      "label": "arthritic joint disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4665,
        8264,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:848",
          "EFO:0005856",
          "MEDGEN:2043",
          "MESH:D001168",
          "NCIT:C2883",
          "SCTID:3723001",
          "UMLS:C0003864",
          "Wikipedia:Arthritis"
        ],
        "synonyms": [
          "arthritis",
          "inflammation of skeletal joint",
          "skeletal joint inflammation",
          "inflammatory disorder of joint"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain."
      },
      "child_count": 39,
      "reference_id": "MONDO:0005578"
    },
    {
      "id": 24405,
      "label": "idiopathic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29381
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:548250",
          "UMLS:C0277553"
        ],
        "synonyms": [
          "idiopathic disorder"
        ],
        "definition": "A disease or disorder for which the cause is of uncertain or unknown."
      },
      "child_count": 79,
      "reference_id": "MONDO:0700007"
    }
  ],
  "children": [
    {
      "id": 18498,
      "label": "polyarticular juvenile idiopathic arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        12534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009730",
          "GARD:0021729",
          "MEDGEN:1622195",
          "Orphanet:404580",
          "SCTID:16044751000119106",
          "UMLS:C4521004"
        ],
        "synonyms": [
          "juvenile polyarthritis",
          "juvenile polyarticular arthritis",
          "polyarticular JIA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0018456"
    },
    {
      "id": 19260,
      "label": "oligoarticular juvenile idiopathic arthritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        12534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1002019",
          "GARD:0004261",
          "MEDGEN:443993",
          "MESH:C536312",
          "NANDO:1200471",
          "NANDO:2201056",
          "NCIT:C119032",
          "Orphanet:85410",
          "UMLS:C2931171",
          "icd11.foundation:1990556904"
        ],
        "synonyms": [
          "Oligoarticular JIA",
          "Pauciarticular JIA",
          "Pauciarticular chronic arthritis",
          "Pauciarticular juvenile idiopathic arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Oligoarticular juvenile arthritis is the most common form of juvenile idiopathic arthritis (JIA), representing nearly 50% of cases."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019433"
    },
    {
      "id": 19261,
      "label": "systemic-onset juvenile idiopathic arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12534,
        19503
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1001999",
          "GARD:0010966",
          "MEDGEN:346934",
          "MESH:C565798",
          "NANDO:1200470",
          "NANDO:2201055",
          "NCIT:C119031",
          "Orphanet:85414",
          "SCTID:201796004",
          "UMLS:C1858558",
          "icd11.foundation:504387587"
        ],
        "synonyms": [
          "SoJIA",
          "Still disease",
          "sJIA",
          "systemic polyarthritis",
          "systemic-onset JIA",
          "Still's disease (formerly)",
          "systemic juvenile idiopathic arthritis",
          "systemic onset juvenile idiopathic arthritis",
          "systemic onset juvenile rheumatoid arthritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Systemic-onset juvenile idiopathic arthritis is marked by the severity of the extra-articular manifestations (fever, cutaneous eruptions) and by an equal sex ratio."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019434"
    },
    {
      "id": 19263,
      "label": "psoriasis-related juvenile idiopathic arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12534,
        12930
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009733",
          "GARD:0010970",
          "MEDGEN:811463",
          "NCIT:C114361",
          "Orphanet:85436",
          "SCTID:239802003",
          "UMLS:C3714758",
          "icd11.foundation:1473955563"
        ],
        "synonyms": [
          "JPsA",
          "juvenile psoriatic arthritis",
          "psoriasis-related JIA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Childhood arthritis typically associated with psoriasis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019436"
    },
    {
      "id": 19264,
      "label": "enthesitis-related juvenile idiopathic arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009732",
          "GARD:0010969",
          "MEDGEN:854059",
          "NANDO:2201060",
          "NCIT:C119024",
          "Orphanet:85438",
          "SCTID:410801005",
          "UMLS:C3495919",
          "icd11.foundation:1128255226"
        ],
        "synonyms": [
          "ERA",
          "enthesitis-related JIA",
          "era",
          "enthesitis related arthritis, juvenile",
          "enthesitis-related arthritis",
          "juvenile enthesitis-related arthritis",
          "juvenile spondylarthropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Enthesitis-related juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and inflammation of an enthesitis site (the point at which a ligament, tendon, or joint capsule attaches to the bone). Signs and symptoms generally develop in late childhood or early adolescence and include pain, tenderness, and swelling in joints and at the enthesis. The knee and the back of the ankle (at the Achilles tendon) are the most commonly affected parts of the body. The underlying cause of enthesitis-related juvenile idiopathic arthritis is currently unknown (idiopathic). It is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. Treatment usually involves different types of medications to help manage symptoms and/or physical therapy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019437"
    },
    {
      "id": 19400,
      "label": "unspecified juvenile idiopathic arthritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009734",
          "GARD:0019155",
          "MEDGEN:1842681",
          "NANDO:2201061",
          "Orphanet:91140",
          "UMLS:C5680196"
        ],
        "synonyms": [
          "unspecified JIA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "Unspecified juvenile idiopathic arthritis is a rare, pediatric, rheumatologic disease, a subtype of juvenile idiopathic arthritis (JIA) characterized by arthritis of an unknown cause that persists for at least 6 weeks, and does not fulfill the criteria for any of the other JIA subtypes, or fulfills criteria for more than one of the other subtypes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019607"
    }
  ],
  "roots": [
    {
      "id": 7203,
      "label": "rheumatic disorder"
    },
    {
      "id": 7223,
      "label": "arthritic joint disease"
    },
    {
      "id": 24405,
      "label": "idiopathic disease"
    }
  ]
}