{
  "id": 12546,
  "label": "complex regional pain syndrome type 1",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011441",
  "properties": {
    "xrefs": [
      "DOID:1811",
      "EFO:1001147",
      "GARD:0016928",
      "ICD10CM:G90.5",
      "ICD9:337.2",
      "ICD9:337.20",
      "ICD9:337.21",
      "ICD9:337.29",
      "ICD9:733.7",
      "MEDGEN:11159",
      "MESH:D012019",
      "MedDRA:10038249",
      "MedDRA:10064334",
      "NCIT:C85042",
      "OMIM:604335",
      "Orphanet:99995",
      "SCTID:50642008",
      "UMLS:C0034931"
    ],
    "synonyms": [
      "Algodystrophy",
      "CRPS I",
      "CRPS1",
      "Complex regional pain syndrome I",
      "RND",
      "RSDS",
      "complex regional pain syndrome type 1",
      "reflex neurovascular dystrophy",
      "reflex sympathetic dystrophy",
      "reflex sympathetic dystrophy syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 19203,
      "label": "complex regional pain syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21350
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14022",
          "DOID:3223",
          "EFO:1001998",
          "GARD:0004647",
          "ICD10CM:M89.0",
          "MEDGEN:96846",
          "MESH:D020918",
          "MedDRA:10064332",
          "NORD:1652",
          "Orphanet:83452",
          "SCTID:128200000",
          "UMLS:C0458219",
          "icd11.foundation:1834504950"
        ],
        "synonyms": [
          "CRPS",
          "algoneurodystrophy",
          "reflex sympathetic dystrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A chronic pain syndrome characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb."
      },
      "child_count": 2,
      "reference_id": "MONDO:0019369"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 19203,
      "label": "complex regional pain syndrome"
    }
  ]
}