{
  "id": 12602,
  "label": "Wolfram syndrome 2",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011502",
  "properties": {
    "xrefs": [
      "DOID:0110630",
      "GARD:0015374",
      "MEDGEN:347604",
      "MESH:C565733",
      "OMIM:604928",
      "UMLS:C1858028"
    ],
    "synonyms": [
      "CISD2 Wolfram syndrome",
      "WFS2",
      "Wolfram syndrome 2",
      "Wolfram syndrome caused by mutation in CISD2",
      "Wolfram syndrome type 2",
      "WOLFRAM syndrome 2"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Any Wolfram syndrome in which the cause of the disease is a mutation in the CISD2 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 18263,
      "label": "Wolfram syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10632",
          "GARD:0007898",
          "ICD9:250.80",
          "MEDGEN:21923",
          "MESH:D014929",
          "NANDO:1200757",
          "NCIT:C35133",
          "Orphanet:3463",
          "SCTID:70694009",
          "UMLS:C0043207",
          "icd11.foundation:151381747"
        ],
        "synonyms": [
          "DIDMOAD",
          "DIDMOAD syndrome",
          "Wolfram syndrome",
          "diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome",
          "diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome",
          "diabetes mellitus and insipidus with optic atrophy and deafness"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018105"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 18263,
      "label": "Wolfram syndrome"
    }
  ]
}