{
  "id": 12755,
  "label": "juvenile primary lateral sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011663",
  "properties": {
    "xrefs": [
      "GARD:0004485",
      "MEDGEN:342870",
      "MESH:C536416",
      "OMIM:606353",
      "Orphanet:247604",
      "SCTID:717964007",
      "UMLS:C1853396"
    ],
    "synonyms": [
      "JPLS",
      "juvenile PLS",
      "PLS juvenile",
      "PLSJ",
      "Pls, juvenile",
      "primary lateral sclerosis, juvenile"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Juvenile primary lateral sclerosis (JPLS) is a very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18300,
      "label": "lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:230",
          "GARD:0010684",
          "ICD10CM:G12.23",
          "ICD9:335.24",
          "MEDGEN:57591",
          "MedDRA:10036704",
          "NANDO:1200008",
          "NCIT:C129933",
          "Orphanet:35689",
          "SCTID:81211007",
          "UMLS:C0154682",
          "icd11.foundation:1686688462"
        ],
        "synonyms": [
          "PLS",
          "adult-onset PLS",
          "adult-onset primary lateral sclerosis",
          "primary lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018155"
    },
    {
      "id": 23968,
      "label": "ALS2-related motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026088"
        ],
        "synonyms": [
          "Alsin-related motor neuron disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any motor neuron disease in which the cause of the disease is a mutation in the ALS2 gene."
      },
      "child_count": 3,
      "reference_id": "MONDO:0100227"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18300,
      "label": "lateral sclerosis"
    },
    {
      "id": 23968,
      "label": "ALS2-related motor neuron disease"
    }
  ]
}