{
  "id": 12762,
  "label": "persistent polyclonal B-cell lymphocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011672",
  "properties": {
    "xrefs": [
      "GARD:0017366",
      "MEDGEN:341117",
      "MESH:C564707",
      "OMIM:606445",
      "Orphanet:300324",
      "SCTID:763864008",
      "UMLS:C1847973"
    ],
    "synonyms": [
      "PPBL",
      "persistent polyclonal B-cell lymphocytosis",
      "persistent polyclonal B-cell lymphocytosis with binucleated lymphocytes"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare, generally benign, lymphoproliferative hematological disease characterized by: chronic, stable, persistent, polyclonal lymphocytosis of memory B-cell origin, the presence of binucleated lymphocytes in the peripheral blood, and a polyclonal increase in serum immunoglobulin M (IgM). Patients are most frequently asymptomatic or may present with mild splenomegaly."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020131",
          "MEDGEN:1842533",
          "Orphanet:171898",
          "UMLS:C5680515"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 4,
      "reference_id": "MONDO:0015757"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16514,
      "label": "lymphoid hemopathy"
    }
  ]
}