{
  "id": 12908,
  "label": "patent ductus arteriosus",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011827",
  "properties": {
    "xrefs": [
      "DOID:13832",
      "GARD:0024824",
      "ICD10CM:Q25.0",
      "ICD9:747.0",
      "MEDGEN:4415",
      "MESH:D004374",
      "NANDO:2100084",
      "NANDO:2200264",
      "NCIT:C84492",
      "OMIMPS:607411",
      "Orphanet:466729",
      "Orphanet:706",
      "SCTID:83330001",
      "UMLS:C0013274",
      "icd11.foundation:1262462321"
    ],
    "synonyms": [
      "PDA",
      "patent ductus arteriosus",
      "patent ductus botalli",
      "persistent patency of the arterial duct",
      "patency of the ductus arteriosus",
      "patent ductus arteriosus familial (type)"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A congenital defect characterized by the failure of the ductus arteriosus to close soon after birth. As a consequence, blood from the aorta mixes with blood from the pulmonary artery. If untreated, it may lead to congestive heart failure."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7065,
      "label": "vascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:178",
          "EFO:0004264",
          "ICD10CM:I00-I99",
          "ICD10CM:I70-I79",
          "ICD9:442.9",
          "MEDGEN:22621",
          "MESH:D014652",
          "NANDO:2100294",
          "NCIT:C35117",
          "SCTID:27550009",
          "UMLS:C0042373"
        ],
        "synonyms": [
          "disease of vasculature",
          "disease or disorder of vasculature",
          "disorder of vasculature",
          "vascular disorder",
          "vasculature disease",
          "vasculature disease or disorder",
          "vasculopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A general term used to describe any disease affecting blood vessels]. It includes vascular abnormalities caused by degenerative, metabolic and inflammatory conditions, embolic diseases, coagulative disorders, and functional disorders such as posteri or reversible encephalopathy syndrome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005385"
    },
    {
      "id": 7116,
      "label": "congenital heart disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6967,
        21294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1682",
          "EFO:0005207",
          "ICD9:746.84",
          "ICD9:746.89",
          "ICD9:746.9",
          "MEDGEN:57501",
          "MESH:D006330",
          "NCIT:C95834",
          "SCTID:13213009",
          "UMLS:C0152021",
          "icd11.foundation:2004408087"
        ],
        "synonyms": [
          "heart malformation",
          "congenital anomaly of heart",
          "congenital heart defect",
          "congenital heart defects",
          "Abnormality, heart",
          "abnormalities, heart",
          "defect, congenital heart",
          "defects, congenital heart",
          "heart abnormalities",
          "heart abnormality",
          "heart defect, congenital",
          "heart, malformation Of"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heart disease that is present at birth. Representative examples include atrial septal defect, ventricular septal defect, tetralogy of Fallot, and patent foramen ovale."
      },
      "child_count": 46,
      "reference_id": "MONDO:0005453"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6967
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "hereditary heart disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A heterogeneous group of genetic conditions, with Mendelian (autosomal dominant, recessive, or X-linked) or chromosomal etiology that are characterized by abnormalities in the cardiovascular system."
      },
      "child_count": 146,
      "reference_id": "MONDO:0100547"
    }
  ],
  "children": [
    {
      "id": 9517,
      "label": "Char syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12908,
        16088,
        24336,
        26520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060563",
          "GARD:0001237",
          "ICD9:759.89",
          "MEDGEN:358356",
          "MESH:C566815",
          "OMIM:169100",
          "Orphanet:46627",
          "SCTID:703534001",
          "UMLS:C1868570"
        ],
        "synonyms": [
          "Char syndrome",
          "patent ductus arteriosus with facial dysmorphism and abnormal fifth digits",
          "CHAR",
          "CHAR syndrome",
          "Char",
          "patent ductus arteriosus with Facial Dysmorphism and abnormal fifth digits"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Char syndrome is characterized by the triad of patent ductus arteriosus (PDA), facial dysmorphism and hand anomalies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008209"
    },
    {
      "id": 15860,
      "label": "patent ductus arteriosus 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12908,
        26520
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018489",
          "MEDGEN:924886",
          "OMIM:617035",
          "UMLS:C4284595"
        ],
        "synonyms": [
          "PDA2",
          "patent ductus arteriosus 2",
          "patent ductus arteriosus 2; PDA2",
          "patent ductus arteriosus type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0014878"
    },
    {
      "id": 21307,
      "label": "patent ductus arteriosus 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12908
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018490",
          "MEDGEN:934720",
          "OMIM:617039",
          "UMLS:C4310753"
        ],
        "synonyms": [
          "PDA3",
          "PRDM6 patent ductus arteriosus",
          "patent ductus arteriosus 3",
          "patent ductus arteriosus caused by mutation in PRDM6"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any patent ductus arteriosus in which the cause of the disease is a mutation in the PRDM6 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024266"
    },
    {
      "id": 21505,
      "label": "PDA1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        12908
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007342",
          "MEDGEN:924232",
          "OMIM:607411",
          "UMLS:C4282128"
        ],
        "synonyms": [
          "PDA1",
          "patent ductus arteriosus, susceptibility to",
          "PDA",
          "patent ductus arteriosus 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0024560"
    }
  ],
  "roots": [
    {
      "id": 7065,
      "label": "vascular disorder"
    },
    {
      "id": 7116,
      "label": "congenital heart disease"
    },
    {
      "id": 24272,
      "label": "cardiogenetic disease"
    }
  ]
}