{
  "id": 12987,
  "label": "Alzheimer disease 3",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0011913",
  "properties": {
    "xrefs": [
      "DOID:0110042",
      "GARD:0016513",
      "MEDGEN:334304",
      "MESH:C536598",
      "NCIT:C123412",
      "OMIM:607822",
      "UMLS:C1843013"
    ],
    "synonyms": [
      "AD3",
      "Alzheimer disease 3",
      "Alzheimer disease type 3",
      "Alzheimer disease, protection against, due to APOE3-Christchurch",
      "Alzheimer disease, type 3",
      "Alzheimer disease, type 3, with spastic paraparesis and apraxia",
      "Alzheimer disease, type 3, with spastic paraparesis and unusual plaques",
      "Alzheimer's disease 3",
      "Alzheimer's disease type 3",
      "PSEN1 early-onset autosomal dominant Alzheimer disease",
      "early-onset autosomal dominant Alzheimer disease caused by mutation in PSEN1",
      "familial Alzheimer disease, type 3",
      "familial Alzheimer's disease, type 3",
      "AD",
      "Alzheimer disease 3, early-onset",
      "Alzheimer disease early onset type 3",
      "Alzheimer disease, familial, 3",
      "Alzheimer disease, familial, 3, with spastic paraparesis and apraxia",
      "Alzheimer disease, familial, 3, with spastic paraparesis and unusual plaques"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN1 gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16078,
      "label": "early-onset autosomal dominant Alzheimer disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2903,
        23839
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0012798",
          "Orphanet:1020"
        ],
        "synonyms": [
          "EOFAD",
          "early-onset familial autosomal dominant Alzheimer disease",
          "early-onset, autosomal dominant Alzheimer disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A progressive dementia with reduction of cognitive functions. It presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old."
      },
      "child_count": 28,
      "reference_id": "MONDO:0015140"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16078,
      "label": "early-onset autosomal dominant Alzheimer disease"
    }
  ]
}