{
  "id": 13129,
  "label": "familial sick sinus syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0012061",
  "properties": {
    "xrefs": [
      "GARD:0013663",
      "MEDGEN:573766",
      "MESH:C563907",
      "MedDRA:10040639",
      "OMIMPS:608567",
      "Orphanet:166282",
      "SCTID:233913007",
      "UMLS:C0340491",
      "icd11.foundation:1495462959"
    ],
    "synonyms": [
      "familial sinus node dysfunction",
      "hereditary sick sinus syndrome",
      "SSS1",
      "sick sinus syndrome 1, autosomal recessive"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "Sick sinus syndrome is a rare cardiac rhythm disease, usually of the elderly, characterized by electrocardiographic findings of sinus bradycardia, atrial fibrillation, atrial tachycardia sinus arrest, or sino-atrial block, and that manifest with symptoms like syncope, dizziness, palpitations, fatigue, or even heart failure. It results from malfunction of the cardiac conduction system, probably secondary to degenerative fibrosis of nodal tissue in the elderly or secondary to cardiac disorders in younger patients."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4004,
      "label": "sick sinus syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2930,
        4370
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13884",
          "ICD10CM:I49.5",
          "MEDGEN:20749",
          "MESH:D012804",
          "NANDO:2100043",
          "NANDO:2200212",
          "NCIT:C62244",
          "SCTID:36083008",
          "UMLS:C0037052",
          "icd11.foundation:1682594333"
        ],
        "synonyms": [
          "SSS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A constellation of signs and symptoms which may include syncope, fatigue, dizziness, and alternating periods of bradycardia and atrial tachycardia, which is caused by sinoatrial node dysfunction."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001823"
    },
    {
      "id": 26601,
      "label": "cardiogenetic rhythm disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8666,
        24272
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "cardiogenetic rhythm disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any cardiac rhythm disorder with a monogenic etiology that includes, but is not limited to, atrial fibrillation, sick sinus syndrome, progressive cardiac conduction disease, ventricular fibrillation, Brugada syndrome, long QT syndrome, short QT syndrome, tachycardia with fibrillation."
      },
      "child_count": 18,
      "reference_id": "MONDO:1010180"
    }
  ],
  "children": [
    {
      "id": 9420,
      "label": "sick sinus syndrome 2, autosomal dominant",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        13129
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018284",
          "MEDGEN:320273",
          "MESH:C563513",
          "OMIM:163800",
          "UMLS:C1834144"
        ],
        "synonyms": [
          "HCN4 sick sinus syndrome",
          "sick sinus syndrome 2, autosomal dominant",
          "sick sinus syndrome caused by mutation in HCN4",
          "SSS2",
          "Sss, autosomal dominant",
          "atrial fibrillation with Bradyarrhythmia",
          "sick sinus syndrome 2",
          "sick sinus syndrome 2 with or without Cardiac noncompaction and/Or ascending aorta dilation",
          "sinus bradycardia syndrome, familial, autosomal dominant",
          "sinus node disease, familial, autosomal dominant"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any sick sinus syndrome in which the cause of the disease is a mutation in the HCN4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0008102"
    },
    {
      "id": 9718,
      "label": "sinus node disease and myopia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        13129
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004880",
          "MEDGEN:401121",
          "MESH:C566690",
          "OMIM:182190",
          "UMLS:C1866960"
        ],
        "synonyms": [
          "sinus node disease and myopia",
          "Sss-myopia syndrome",
          "sick sinus syndrome and myopia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0008423"
    },
    {
      "id": 21507,
      "label": "sick sinus syndrome 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        13129,
        26602
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025432",
          "MEDGEN:325270",
          "OMIM:608567",
          "UMLS:C1837845"
        ],
        "synonyms": [
          "SCN5A sick sinus syndrome",
          "sick sinus syndrome 1",
          "sick sinus syndrome caused by mutation in SCN5A",
          "SSS1",
          "sick sinus syndrome, congenital",
          "sinus bradycardia syndrome, familial",
          "sinus node disease, familial, autosomal recessive",
          "sinus rhythm, congenital absence of"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any sick sinus syndrome in which the cause of the disease is a mutation in the SCN5A gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024562"
    },
    {
      "id": 25317,
      "label": "sick sinus syndrome 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        13129
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026663",
          "MEDGEN:1794159",
          "OMIM:619464",
          "UMLS:C5561949"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0859173"
    }
  ],
  "roots": [
    {
      "id": 4004,
      "label": "sick sinus syndrome"
    },
    {
      "id": 26601,
      "label": "cardiogenetic rhythm disorder"
    }
  ]
}