{
  "id": 13569,
  "label": "herpes simplex encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0012521",
  "properties": {
    "xrefs": [
      "GARD:0006649",
      "MEDGEN:75794",
      "MESH:D020803",
      "NANDO:2200772",
      "NCIT:C84762",
      "NORD:1087",
      "Orphanet:1930",
      "UMLS:C0276226",
      "icd11.foundation:320069644"
    ],
    "synonyms": [
      "Encephalitis, Herpes Simplex",
      "HSE",
      "HSV encephalitis",
      "HSVE",
      "Herpes simplex meningo-encephalitis",
      "Herpes simplex neuroinvasion",
      "Simplexvirus caused infectious encephalitis",
      "Simplexvirus infectious encephalitis",
      "herpetic encephalitis",
      "Herpes simplex virus encephalitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Herpes simplex virus encephalitis (HSE) is caused by the infection of the central nervous system by Herpes simplex virus (HSV) that could have a devastating clinical course and a potentially fatal outcome particularly with delay or lack of treatment. HSV often involves the frontal and temporal lobes, usually asymmetrically, resulting in personality changes, cognitive impairment, aphasia, seizures, and focal weakness."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6399,
      "label": "herpes simplex infectious disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7411
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8566",
          "EFO:1002022",
          "ICD10CM:B00",
          "ICD9:054",
          "ICD9:058.89",
          "MEDGEN:9234",
          "MESH:D006561",
          "SCTID:88594005",
          "UMLS:C0019348"
        ],
        "synonyms": [
          "Simplexvirus caused disease or disorder",
          "Simplexvirus disease or disorder",
          "Simplexvirus infectious disease",
          "herpes simplex",
          "herpes simplex complex",
          "herpes simplex infection",
          "herpes simplex viral infection"
        ],
        "definition": "A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0004609"
    },
    {
      "id": 7600,
      "label": "viral encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19721,
        21351,
        24062
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:646",
          "EFO:0007538",
          "GARD:0019433",
          "MEDGEN:116719",
          "MedDRA:10058805",
          "NCIT:C35302",
          "Orphanet:98252",
          "SCTID:34476008",
          "UMLS:C0243010"
        ],
        "synonyms": [
          "Viruses caused encephalitis",
          "Viruses encephalitis",
          "viral encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Encephalitis resulting from viral infection."
      },
      "child_count": 36,
      "reference_id": "MONDO:0006009"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6399,
      "label": "herpes simplex infectious disease"
    },
    {
      "id": 7600,
      "label": "viral encephalitis"
    }
  ]
}