{
  "id": 13626,
  "label": "autoimmune pulmonary alveolar proteinosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0012579",
  "properties": {
    "xrefs": [
      "GARD:0007499",
      "MEDGEN:410079",
      "MESH:C567049",
      "NANDO:1200747",
      "NANDO:1200748",
      "NORD:1633",
      "OMIM:610910",
      "Orphanet:747",
      "SCTID:707443007",
      "UMLS:C1970472",
      "icd11.foundation:676409940"
    ],
    "synonyms": [
      "APAP",
      "Pulmonary Alveolar Proteinosis",
      "autoimmune PAP",
      "iPAP",
      "idiopathic PAP",
      "idiopathic pulmonary alveolar proteinosis",
      "PAP",
      "PAP acquired",
      "Pap, acquired",
      "acquired pulmonary alveolar proteinosis",
      "pulmonary alveolar lipoproteinosis acquired",
      "pulmonary alveolar lipoproteinosis, acquired",
      "pulmonary alveolar proteinosis acquired",
      "pulmonary alveolar proteinosis autoimmune",
      "pulmonary alveolar proteinosis, acquired",
      "pulmonary alveolar proteinosis, autoimmune"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of a lipoproteinaceous substance in the distal air spaces which positively stains with periodic acid-Schiff (PAS)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3655,
      "label": "pulmonary alveolar proteinosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12120",
          "ICD9:516.0",
          "MEDGEN:1763046",
          "MESH:D011649",
          "NANDO:1200746",
          "NCIT:C85037",
          "SCTID:10501004",
          "UMLS:C5400698",
          "icd11.foundation:1869739196"
        ],
        "synonyms": [
          "PAP",
          "pulmonary alveolar proteinosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare lung disorder characterized by the filling of the pulmonary alveoli with proteinaceous material which stains positive with periodic acid-Schiff stain. It may be idiopathic or secondary due to hematologic malignancies or the inhalation of mineral dusts. Signs and symptoms include dyspnea, cough and low grade fever."
      },
      "child_count": 3,
      "reference_id": "MONDO:0001437"
    },
    {
      "id": 8586,
      "label": "autoimmune disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:417",
          "EFO:0005809",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:720",
          "MEDGEN:2135",
          "MESH:D001327",
          "NCIT:C2889",
          "OBI:1110054",
          "OMIM:109100",
          "SCTID:85828009",
          "UMLS:C0004364"
        ],
        "synonyms": [
          "autoimmune disease",
          "autoimmune disease or disorder",
          "autoimmune disorder",
          "disease, autoimmune",
          "autoimmune hypersensitivity disease",
          "hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis)."
      },
      "child_count": 47,
      "reference_id": "MONDO:0007179"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3655,
      "label": "pulmonary alveolar proteinosis"
    },
    {
      "id": 8586,
      "label": "autoimmune disease"
    }
  ]
}