{
  "id": 13830,
  "label": "amyotrophic lateral sclerosis type 10",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0012790",
  "properties": {
    "xrefs": [
      "DOID:0060201",
      "GARD:0015540",
      "MEDGEN:383137",
      "MESH:C567429",
      "OMIM:612069",
      "UMLS:C2677565"
    ],
    "synonyms": [
      "ALS10",
      "TARDBP amyotrophic lateral sclerosis",
      "amyotrophic lateral sclerosis 10, with or without FTD",
      "amyotrophic lateral sclerosis caused by mutation in TARDBP",
      "amyotrophic lateral sclerosis type 10",
      "frontotemporal lobar degeneration, TARDBP-related",
      "Ftld-TDP, Tardbp-related",
      "amyotrophic lateral sclerosis 10 with or without frontotemporal dementia",
      "frontotemporal dementia with Tdp43 inclusions, Tardbp-related",
      "frontotemporal lobar Degeneration with Tdp43 inclusions, Tardbp-related"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the TARDBP gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6718,
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001356",
          "GARD:0024155",
          "MEDGEN:1642547",
          "OMIMPS:105400",
          "UMLS:C4551993"
        ],
        "synonyms": [
          "hereditary amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005144"
    },
    {
      "id": 17506,
      "label": "frontotemporal dementia with motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7073,
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017273",
          "MEDGEN:854771",
          "MESH:C566288",
          "OMIMPS:105550",
          "Orphanet:275872",
          "UMLS:C3888102",
          "icd11.foundation:1171850356"
        ],
        "synonyms": [
          "FTD-ALS",
          "FTD-MND",
          "FTDALS",
          "frontotemporal dementia with ALS",
          "frontotemporal dementia with amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual impairment, emotional disorders and transcortical motor aphasia that eventually leads to mutism, in addition to the manifestations of motor neuron disease such as neurogenic muscular wasting (similar to what is seen in amyotrophic lateral sclerosis). The disease is progressive, with death occurring 2-5 years after onset."
      },
      "child_count": 21,
      "reference_id": "MONDO:0017161"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis"
    },
    {
      "id": 17506,
      "label": "frontotemporal dementia with motor neuron disease"
    }
  ]
}