{
  "id": 13923,
  "label": "acute promyelocytic leukemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0012883",
  "properties": {
    "xrefs": [
      "DOID:0060318",
      "DOID:0081081",
      "EFO:0000224",
      "GARD:0000538",
      "ICD10CM:C92.4",
      "ICDO:9866/3",
      "MEDGEN:44127",
      "MESH:D015473",
      "MedDRA:10001019",
      "NANDO:2200007",
      "NCIT:C3182",
      "NORD:2003",
      "OMIM:612376",
      "Orphanet:520",
      "SCTID:110004001",
      "UMLS:C0023487"
    ],
    "synonyms": [
      "AML M3",
      "AML with t(15;17)(q22;q12)",
      "AML with t(15;17)(q22;q12);(PML/RARalpha) and variants",
      "APL",
      "APML",
      "APML - acute promyelocytic leukaemia",
      "APML - acute promyelocytic leukemia",
      "FAB M3",
      "acute myeloblastic leukaemia 3",
      "acute myeloblastic leukemia 3",
      "acute myeloid leukaemia with t(15;17)(q22;q12);(PML/RARalpha) and variants",
      "acute myeloid leukemia with t(15;17)(q22;q12);(PML/RARalpha) and variants",
      "acute promyelocytic leukaemia with PML-rara",
      "acute promyelocytic leukaemia with t(15;17)(q22;q12); PML-rara",
      "acute promyelocytic leukaemia with t(15;17)(q22;q12); PML/rara",
      "acute promyelocytic leukemia",
      "acute promyelocytic leukemia with PML-rara",
      "acute promyelocytic leukemia with t(15;17)(q22;q12); PML-rara",
      "acute promyelocytic leukemia with t(15;17)(q22;q12); PML/rara",
      "leukemia, acute promyelocytic, somatic",
      "promyelocytic leukaemia",
      "promyelocytic leukemia",
      "leukemia, acute promyelocytic"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An aggressive form of acute myeloid leukemia (AML), characterized by arrest of leukocyte differentiation at the promyelocyte stage, due to a specific chromosomal translocation t(15;17) in myeloid cells. APL manifests with easy bruising, hemorrhagic diathesis and fatigue."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 18103,
      "label": "inherited acute myeloid leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18806,
        21247
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017450",
          "MEDGEN:1634915",
          "NCIT:C7175",
          "Orphanet:319465",
          "SCTID:764940002",
          "UMLS:C4707228"
        ],
        "synonyms": [
          "Pure familial AML",
          "Pure familial acute myeloid leukaemia",
          "Pure familial acute myeloid leukemia",
          "familial AML",
          "hereditary acute myeloid leukaemia",
          "hereditary acute myeloid leukemia",
          "inherited AML"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of acute myeloid leukemia that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017893"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 18103,
      "label": "inherited acute myeloid leukemia"
    }
  ]
}