{
  "id": 14465,
  "label": "primary sclerosing cholangitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0013433",
  "properties": {
    "xrefs": [
      "DOID:0060643",
      "GARD:0001280",
      "ICD10CM:K83.01",
      "MEDGEN:107565",
      "MedDRA:10036732",
      "NANDO:1200440",
      "NANDO:2100265",
      "NORD:1613",
      "OMIM:613806",
      "Orphanet:171",
      "SCTID:197441003",
      "UMLS:C0566602",
      "icd11.foundation:857962451"
    ],
    "synonyms": [
      "PSC",
      "cholangitis, primary sclerosing"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Primary sclerosing cholangitis (PSC) is a rare, slowly progressive liver disease characterized by inflammation and destruction of the intra- and/or extra-hepatic bile ducts that lead to cholestasis, liver fibrosis, liver cirrhosis and ultimately liver failure."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 18642,
      "label": "sclerosing cholangitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6556
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14268",
          "EFO:0004268",
          "GARD:0021868",
          "HP:0030991",
          "MEDGEN:3036",
          "NANDO:1200440",
          "NANDO:2100265",
          "NCIT:C4828",
          "Orphanet:447771",
          "SCTID:235917005",
          "UMLS:C0008313"
        ],
        "synonyms": [
          "Primary sclerosing cholangitis",
          "primary sclerosing cholangitis (PSC)",
          "sclerosing cholangitis",
          "sclerosing cholangitis (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure."
      },
      "child_count": 5,
      "reference_id": "MONDO:0018646"
    }
  ],
  "children": [
    {
      "id": 12321,
      "label": "nephropathy, progressive tubulointerstitial, with cholestatic liver disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        14465
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015344",
          "MEDGEN:355562",
          "MESH:C566573",
          "OMIM:602114",
          "UMLS:C1865831"
        ],
        "synonyms": [
          "nephropathy, progressive tubulointerstitial, with cholestatic liver disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011199"
    }
  ],
  "roots": [
    {
      "id": 18642,
      "label": "sclerosing cholangitis"
    }
  ]
}