{
  "id": 14742,
  "label": "complement component 4a deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0013721",
  "properties": {
    "xrefs": [
      "DOID:0060297",
      "GARD:0015798",
      "MEDGEN:482272",
      "MESH:C565167",
      "OMIM:614380",
      "UMLS:C3280642"
    ],
    "synonyms": [
      "C4A classic complement early component deficiency",
      "classic complement early component deficiency caused by mutation in C4A",
      "complement component 4a deficiency",
      "C4A deficiency",
      "C4AD",
      "complement component 4A deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Any classic complement early component deficiency in which the cause of the disease is a mutation in the C4A gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2704,
      "label": "classic complement early component deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5701
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009526",
          "ICD9:279.8",
          "MEDGEN:226929",
          "SCTID:363009005",
          "UMLS:C1285186"
        ],
        "synonyms": [
          "genetic deficiency of early component of the classical complement pathway"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) that is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response."
      },
      "child_count": 13,
      "reference_id": "MONDO:0000015"
    },
    {
      "id": 16463,
      "label": "immunodeficiency due to a classical component pathway complement deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5701
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0015025",
          "MEDGEN:585054",
          "Orphanet:169147",
          "UMLS:C0398750",
          "icd11.foundation:327609494"
        ],
        "synonyms": [
          "immunodeficiency due to C1, C4, or C2 component complement deficiency",
          "immunodeficiency due to a C1, C4, or C2 component complement deficiency",
          "immunodeficiency due to an early component of complement deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0015699"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2704,
      "label": "classic complement early component deficiency"
    },
    {
      "id": 16463,
      "label": "immunodeficiency due to a classical component pathway complement deficiency"
    }
  ]
}