{
  "id": 14751,
  "label": "graft versus host disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0013730",
  "properties": {
    "xrefs": [
      "DOID:0081267",
      "GARD:0016642",
      "ICD10CM:D89.81",
      "ICD9:279.50",
      "MEDGEN:9082",
      "MESH:D006086",
      "MedDRA:10018651",
      "NCIT:C3063",
      "NORD:1203",
      "Orphanet:39812",
      "SCTID:234646005",
      "UMLS:C0018133",
      "icd11.foundation:437372167"
    ],
    "synonyms": [
      "GVH",
      "GVHD",
      "GvHD",
      "disease, graft-versus-host",
      "disease, graft-vs-host",
      "diseases, graft-versus-host",
      "diseases, graft-vs-host",
      "graft versus host disease",
      "graft vs host disease",
      "graft vs. host disease",
      "graft-versus-host disease",
      "graft-versus-host-disease",
      "graft-vs-host disease",
      "runt disease",
      "disease, homologous wasting",
      "disease, runt",
      "graft-VS-host diseases",
      "graft-versus-host disease, resistance to",
      "graft-versus-host disease, susceptibility to",
      "graft-versus-host diseases",
      "homologous wasting disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "An immune system disorder that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6778,
      "label": "immune system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2914",
          "EFO:0000540",
          "ICD9:279",
          "ICD9:279.1",
          "ICD9:279.10",
          "ICD9:279.19",
          "ICD9:279.4",
          "ICD9:279.49",
          "ICD9:279.8",
          "ICD9:279.9",
          "MEDGEN:5759",
          "MESH:D007154",
          "NANDO:1100004",
          "NANDO:2100202",
          "NCIT:C3507",
          "SCTID:414029004",
          "UMLS:C0021053"
        ],
        "synonyms": [
          "disease of immune system",
          "disease or disorder of immune system",
          "disorder of immune system",
          "immune disease",
          "immune disorder",
          "immune dysfunction",
          "immune system disease or disorder",
          "immune system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder resulting from an abnormality in the immune system."
      },
      "child_count": 47,
      "reference_id": "MONDO:0005046"
    },
    {
      "id": 24617,
      "label": "disease related to hematopoietic stem cell transplant",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026374"
        ],
        "definition": "Disease that occurs as a consequence of immunosuppression in a recipient of a hematopoietic stem cell transplant, or as a consequence of the transplantation."
      },
      "child_count": 2,
      "reference_id": "MONDO:0700222"
    }
  ],
  "children": [
    {
      "id": 19990,
      "label": "acute graft versus host disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        14751,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006544",
          "ICD10CM:D89.810",
          "ICD9:279.51",
          "MEDGEN:208987",
          "MedDRA:10066260",
          "NCIT:C4980",
          "Orphanet:99920",
          "SCTID:402355000",
          "UMLS:C0856825",
          "icd11.foundation:83784921"
        ],
        "synonyms": [
          "GVHD, acute",
          "acute graft vs. host disease",
          "fulminant graft versus host disease",
          "graft versus host disease, acute",
          "acute GVHD"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020546"
    },
    {
      "id": 19991,
      "label": "chronic graft versus host disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        14751
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010964",
          "ICD10CM:D89.811",
          "ICD9:279.52",
          "MEDGEN:167851",
          "MedDRA:10066261",
          "NANDO:2100213",
          "NANDO:2200812",
          "NCIT:C4981",
          "Orphanet:99921",
          "SCTID:402356004",
          "UMLS:C0867389",
          "icd11.foundation:621183043"
        ],
        "synonyms": [
          "GVHD, chronic",
          "graft versus host disease, chronic",
          "chronic GVHD"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Chronic graft versus host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted donor cells attack the transplant recipient's body. Symptoms may include skin rash, mouth sores, dry eyes, liver inflammation, development of scar tissue in the skin and joints, and damage to the lungs. The exact cause of chronic GVHD is unknown.It likely results from a complex immune-mediated interaction between the donor and recipient cells.Chronic GVHD is treated with prednisone or other similar anti-inflammatory or immunosuppressive medications."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020547"
    }
  ],
  "roots": [
    {
      "id": 6778,
      "label": "immune system disorder"
    },
    {
      "id": 24617,
      "label": "disease related to hematopoietic stem cell transplant"
    }
  ]
}