{
  "id": 15015,
  "label": "immunoglobulin-mediated membranoproliferative glomerulonephritis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0014005",
  "properties": {
    "xrefs": [
      "DOID:0080388",
      "GARD:0017506",
      "MEDGEN:767244",
      "NANDO:1200726",
      "NCIT:C123055",
      "OMIM:615008",
      "Orphanet:329903",
      "UMLS:C3554330"
    ],
    "synonyms": [
      "Ig-mediated MPGN",
      "Ig-mediated membranoproliferative glomerulonephritis",
      "NPHS7",
      "immune complex mediated membranoproliferative glomerulonephritis",
      "immunoglobulin-mediated MPGN",
      "immunoglobulin-mediated membranoproliferative glomerulonephritis",
      "membranoproliferative glomerulonephritis type I",
      "mesangiocapillary glomerulonephritis type 1",
      "nephrotic syndrome, type 7",
      "nephrotic syndrome, type 7, with membranoproliferative glomerulonephritis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "Glomerulonephritis characterized by mesangial proliferation, endocapillary proliferation, and glomerular capillary wall remodeling with immune complex deposits from classical complement pathway activation."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4449,
      "label": "familial nephrotic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7058,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2590",
          "GARD:0027602",
          "MEDGEN:502251",
          "NCIT:C35337",
          "OMIMPS:256300",
          "SCTID:48796009",
          "UMLS:C3501848",
          "icd11.foundation:1524476844"
        ],
        "synonyms": [
          "congenital nephrotic syndrome",
          "hereditary nephrotic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "An instance of nephrotic syndrome that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002350"
    },
    {
      "id": 7021,
      "label": "hereditary nephritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3410,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:10305",
          "MESH:D009394",
          "SCTID:399340005",
          "UMLS:C0027706"
        ],
        "synonyms": [
          "hereditary nephritis",
          "familial nephritis",
          "nephritis, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A group of inherited conditions characterized initially by hematuria and slowly progressing to renal insufficiency. The most common form is the Alport syndrome (hereditary nephritis with hearing loss) which is caused by mutations in genes for type IV collagen and defective glomerular basement membrane."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005334"
    },
    {
      "id": 18832,
      "label": "primary membranoproliferative glomerulonephritis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011982",
          "ICD9:583.2",
          "MedDRA:10018370",
          "NANDO:1200725",
          "NANDO:2200123",
          "Orphanet:54370"
        ],
        "synonyms": [
          "MPGN",
          "Mesangiocapillary glomerulonephritis",
          "membranoproliferative glomerulonephritis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare glomerular disease characterized by a pattern of glomerular injury on kidney biopsy with characteristic light microscopic changes: mesangial hypercellularity, endocapillary proliferation, and thickening of the glomerular basement membrane (GBM). On the basis of immunofluorescence (IF) the disorder is divided into C3 glomerulopathy (C3G) or immunoglobulin-mediated membranoproliferative glomerulonephritis. Through electron microscopy C3G is further divided into Dense deposit disease, with highly electrondense deposits in the glomerular basement membrane, and C3 glomerulonephritis, with mesangial, intramembranous, subendothelial and subepithelial deposits. Secondary causes (autoimmune, infectious, malignancies) are excluded."
      },
      "child_count": 3,
      "reference_id": "MONDO:0018904"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4449,
      "label": "familial nephrotic syndrome"
    },
    {
      "id": 7021,
      "label": "hereditary nephritis"
    },
    {
      "id": 18832,
      "label": "primary membranoproliferative glomerulonephritis"
    }
  ]
}