{
  "id": 15227,
  "label": "triosephosphate isomerase deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0014221",
  "properties": {
    "xrefs": [
      "DOID:0050884",
      "GARD:0005287",
      "ICD9:282.3",
      "MEDGEN:349893",
      "MESH:C566029",
      "NCIT:C131652",
      "NORD:1793",
      "OMIM:615512",
      "Orphanet:868",
      "SCTID:234405009",
      "UMLS:C1860808"
    ],
    "synonyms": [
      "hemolytic anaemia due to triosephosphate isomerase deficiency",
      "hemolytic anemia due to triosephosphate isomerase deficiency",
      "triose phosphate-isomerase deficiency",
      "triosephosphate isomerase deficiency",
      "TPI deficiency",
      "TPID"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Triosephosphate isomerase (TPI) deficiency is a severe autosomal recessive inherited multisystem disorder of glycolytic metabolism characterized by hemolytic anemia and neurodegeneration."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4915,
      "label": "glucose metabolism disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6795
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4194",
          "EFO:0009406",
          "ICD9:271.8",
          "MEDGEN:226229",
          "MESH:D044882",
          "NCIT:C53655",
          "SCTID:126877002",
          "UMLS:C1257958"
        ],
        "synonyms": [
          "disorder of glucose metabolism",
          "glucose metabolism disorder"
        ],
        "definition": "A metabolic disorder characterized by abnormal blood glucose levels."
      },
      "child_count": 9,
      "reference_id": "MONDO:0002908"
    },
    {
      "id": 5573,
      "label": "familial hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5550,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:589",
          "GARD:0006167",
          "ICD9:282",
          "ICD9:282.9",
          "MEDGEN:1919",
          "MESH:D000745",
          "NANDO:2100183",
          "NCIT:C34379",
          "SCTID:42601008",
          "UMLS:C0002881"
        ],
        "synonyms": [
          "congenital hemolytic anemia",
          "hereditary hemolytic anemia",
          "anaemia hemolytic congenital",
          "anemia hemolytic congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies."
      },
      "child_count": 46,
      "reference_id": "MONDO:0003689"
    },
    {
      "id": 17928,
      "label": "disorder of glycolysis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17229,
        19082,
        19115
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021306",
          "MEDGEN:1825948",
          "Orphanet:308459",
          "UMLS:C5681073"
        ]
      },
      "child_count": 48,
      "reference_id": "MONDO:0017688"
    },
    {
      "id": 20022,
      "label": "anemia due to erythrocyte enzyme disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20021
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025178",
          "MEDGEN:1383362",
          "NCIT:C131630",
          "UMLS:C4329304"
        ],
        "synonyms": [
          "anemia due to erythrocyte enzyme disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Any form of anemia that results from the absence of, or the defective action of, any enzyme involved in erythropoiesis."
      },
      "child_count": 9,
      "reference_id": "MONDO:0020585"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4915,
      "label": "glucose metabolism disease"
    },
    {
      "id": 5573,
      "label": "familial hemolytic anemia"
    },
    {
      "id": 17928,
      "label": "disorder of glycolysis"
    },
    {
      "id": 20022,
      "label": "anemia due to erythrocyte enzyme disorder"
    }
  ]
}