{
  "id": 15390,
  "label": "familial median cleft of the upper and lower lips",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0014388",
  "properties": {
    "xrefs": [
      "DOID:0080407",
      "GARD:0017663",
      "MEDGEN:863033",
      "OMIM:615892",
      "Orphanet:401942",
      "UMLS:C4014596"
    ],
    "synonyms": [
      "OFC14",
      "orofacial cleft 14"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "Familial median cleft of the upper and lower lips is a rare and isolated orofacial defect characterized by incomplete median clefts of both the lower lip (limited to the vermilion, with no muscle involvement) and upper lip (with muscle involvement), double labial frenulum and fusion of the upper gingival and upper labial mucosa (resulting in a shallow upper vestibular fold), in addition to poor dental alignment, and increased interdental distance between the lower and upper median incisors. Variable expressivity has been reported in an affected family."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2863,
      "label": "orofacial cleft",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        21213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050567",
          "MEDGEN:472000",
          "OMIMPS:119530",
          "SCTID:449790007",
          "UMLS:C3266076"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disorder of facial skeleton that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development."
      },
      "child_count": 32,
      "reference_id": "MONDO:0000358"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2863,
      "label": "orofacial cleft"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}