{
  "id": 15424,
  "label": "vesicoureteral reflux 8",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0014422",
  "properties": {
    "xrefs": [
      "GARD:0018425",
      "MEDGEN:863268",
      "OMIM:615963",
      "UMLS:C4014831"
    ],
    "synonyms": [
      "TNXB vesicoureteral reflux (disease)",
      "vesicoureteral reflux (disease) caused by mutation in TNXB",
      "vesicoureteral reflux 8",
      "vesicoureteral reflux type 8",
      "VUR8"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Any vesicoureteral reflux in which the cause of the disease is a mutation in the TNXB gene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17648,
      "label": "familial vesicoureteral reflux",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        7598
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017323",
          "MEDGEN:1637583",
          "OMIMPS:193000",
          "Orphanet:289365",
          "SCTID:763716008",
          "UMLS:C4706552"
        ],
        "synonyms": [
          "familial VUR",
          "hereditary vesicoureteral reflux (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Familial vesicoureteral reflux is a rare, non-syndromic urogenital tract malformation characterized by the familial occurrence of retrograde flow of urine from the bladder into the ureter and sometimes the kidneys. Patients may be asymptomatic or may present with recurrent, sometimes febrile, urinary tract infections that, in case of acute pyelonephritis, may lead to serious complications (renal scarring, hypertension, renal failure). Spontaneous resolution of the disorder is possible."
      },
      "child_count": 18,
      "reference_id": "MONDO:0017329"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17648,
      "label": "familial vesicoureteral reflux"
    }
  ]
}