{
  "id": 15637,
  "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0014641",
  "properties": {
    "xrefs": [
      "DOID:0110069",
      "GARD:0018398",
      "MEDGEN:902979",
      "OMIM:616439",
      "UMLS:C4225325"
    ],
    "synonyms": [
      "FTDALS4",
      "frontotemporal dementia and/or amyotrophic lateral sclerosis 4",
      "frontotemporal dementia and/or amyotrophic lateral sclerosis type 4"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An amyotrophic lateral sclerosis that has material basis in mutation in the TBK1 gene on chromosome 12q14."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6718,
        21302
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0001356",
          "GARD:0024155",
          "MEDGEN:1642547",
          "OMIMPS:105400",
          "UMLS:C4551993"
        ],
        "synonyms": [
          "hereditary amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005144"
    },
    {
      "id": 17506,
      "label": "frontotemporal dementia with motor neuron disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7073,
        16360,
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0017273",
          "MEDGEN:854771",
          "MESH:C566288",
          "OMIMPS:105550",
          "Orphanet:275872",
          "UMLS:C3888102",
          "icd11.foundation:1171850356"
        ],
        "synonyms": [
          "FTD-ALS",
          "FTD-MND",
          "FTDALS",
          "frontotemporal dementia with ALS",
          "frontotemporal dementia with amyotrophic lateral sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual impairment, emotional disorders and transcortical motor aphasia that eventually leads to mutism, in addition to the manifestations of motor neuron disease such as neurogenic muscular wasting (similar to what is seen in amyotrophic lateral sclerosis). The disease is progressive, with death occurring 2-5 years after onset."
      },
      "child_count": 21,
      "reference_id": "MONDO:0017161"
    },
    {
      "id": 22128,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21292
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025663",
          "OMIMPS:105500"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0030923"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6868,
      "label": "familial amyotrophic lateral sclerosis"
    },
    {
      "id": 17506,
      "label": "frontotemporal dementia with motor neuron disease"
    },
    {
      "id": 22128,
      "label": "frontotemporal dementia and/or amyotrophic lateral sclerosis"
    }
  ]
}