{
  "id": 16036,
  "label": "gastric neuroendocrine tumor, well differentiated, low or intermediate grade",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015062",
  "properties": {
    "xrefs": [
      "GARD:0025056",
      "MEDGEN:474032",
      "NCIT:C95871",
      "ONCOTREE:SWDNET",
      "UMLS:C3272399"
    ],
    "synonyms": [
      "GNET",
      "gastric NET",
      "gastric NET G1/2",
      "gastric neuroendocrine tumor",
      "gastric neuroendocrine tumour",
      "gastric well differentiated endocrine tumor",
      "gastric well differentiated endocrine tumor/carcinoma",
      "gastric well differentiated endocrine tumour",
      "well-differentiated neuroendocrine tumors of the stomach",
      "well-differentiated neuroendocrine tumours of the stomach"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the stomach."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 5092,
      "label": "gastric neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20326,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4715",
          "GARD:0019750",
          "MEDGEN:232548",
          "NCIT:C5696",
          "Orphanet:100075",
          "SCTID:721194008",
          "UMLS:C1333783"
        ],
        "synonyms": [
          "NET of stomach",
          "gastric neuroendocrine neoplasm",
          "neuroendocrine neoplasm of stomach",
          "neuroendocrine neoplasm of the stomach",
          "neuroendocrine tumour of the stomach",
          "stomach NET",
          "stomach neuroendocrine neoplasm",
          "stomach neuroendocrine tumor",
          "stomach neuroendocrine tumor, well differentiated, low or intermediate grade",
          "stomach neuroendocrine tumour",
          "neuroendocrine tumor of stomach",
          "neuroendocrine tumour of stomach"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the stomach. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003111"
    }
  ],
  "children": [
    {
      "id": 5435,
      "label": "gastric gastrin-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5434,
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5579",
          "GARD:0023547",
          "MEDGEN:232230",
          "NCIT:C27444",
          "UMLS:C1333767"
        ],
        "synonyms": [
          "gastric G-cell gastrin producing tumour",
          "gastric gastrin producing tumor",
          "gastric gastrin producing tumour",
          "gastric gastrin-producing NET",
          "gastric gastrin-producing neuroendocrine tumor",
          "gastrin producing neuroendocrine tumor of the stomach",
          "gastrin producing neuroendocrine tumour of the stomach",
          "gastrin producing tumor of the stomach",
          "gastrin producing tumour of the stomach",
          "gastrin-producing neuroendocrine tumor of stomach",
          "gastrin-producing neuroendocrine tumor of the stomach",
          "gastrin-producing neuroendocrine tumour of stomach",
          "gastrin-producing neuroendocrine tumour of the stomach",
          "stomach gastrin-producing neuroendocrine tumor",
          "stomach gastrin-producing neuroendocrine tumour",
          "gastric gastrinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated neuroendocrine tumor that arises from the stomach. It produces gastrin and it may be associated with Zollinger-Ellison syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003524"
    },
    {
      "id": 7780,
      "label": "gastric neuroendocrine tumor G1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7051,
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000275",
          "GARD:0024341",
          "MEDGEN:83885",
          "NCIT:C4635",
          "UMLS:C0349529"
        ],
        "synonyms": [
          "gastric ECL cell NET",
          "gastric ECL cell NET G1",
          "gastric ECL cell, histamine-producing NET",
          "gastric ECL-cell carcinoid tumor",
          "gastric ECL-cell carcinoid tumour",
          "gastric NET G1",
          "gastric carcinoid tumor",
          "gastric carcinoid tumour",
          "gastric enterochromaffin-like cell carcinoid tumor",
          "gastric enterochromaffin-like cell carcinoid tumour",
          "gastric enterochromaffin-like cell neuroendocrine tumor",
          "gastric enterochromaffin-like cell neuroendocrine tumour",
          "grade 1 neuroendocrine neoplasm of stomach",
          "stomach NET G1",
          "stomach carcinoid tumor",
          "stomach carcinoid tumour",
          "stomach neuroendocrine neoplasm G1",
          "stomach neuroendocrine tumor, well differentiated, low grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the stomach. The vast majority of cases arise from the corpus-fundus region. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. It may be associated with autoimmune chronic atrophic gastritis, multiple endocrine neoplasia type 1, or it may be sporadic."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006227"
    },
    {
      "id": 18712,
      "label": "familial gastric type 1 neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021932",
          "MEDGEN:1826112",
          "Orphanet:464756",
          "UMLS:C5681095"
        ],
        "synonyms": [
          "familial type 1 gNET",
          "hereditary type 1 gNET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018742"
    },
    {
      "id": 21550,
      "label": "gastric enterochromaffin cell serotonin-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025442",
          "MEDGEN:475770",
          "NCIT:C27443",
          "UMLS:C3274137"
        ],
        "synonyms": [
          "gastric EC cell serotonin-producing NET",
          "gastric EC-cell serotonin-producing neuroendocrine tumor",
          "gastric EC-cell serotonin-producing neuroendocrine tumour",
          "gastric enterochromaffin cell serotonin-producing neuroendocrine tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated neuroendocrine tumor that arises from the stomach. It produces serotonin and it may occasionally be found in association with a carcinoid syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024639"
    },
    {
      "id": 21551,
      "label": "gastric neuroendocrine tumor G2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025443",
          "MEDGEN:474040",
          "NCIT:C95880",
          "UMLS:C3272407"
        ],
        "synonyms": [
          "gastric NET G2",
          "gastric neuroendocrine tumor G2"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, intermediate grade tumor with neuroendocrine differentiation that arises from the stomach. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024642"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 5092,
      "label": "gastric neuroendocrine neoplasm"
    }
  ]
}