{
  "id": 16040,
  "label": "neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015066",
  "properties": {
    "xrefs": [
      "GARD:0019754",
      "MEDGEN:474400",
      "NCIT:C96422",
      "ONCOTREE:AWDNET",
      "Orphanet:100079",
      "SCTID:725167001",
      "UMLS:C3272767",
      "icd11.foundation:1590340268"
    ],
    "synonyms": [
      "NEN of appendix",
      "appendiceal NEN",
      "appendiceal neuroendocrine neoplasm",
      "appendiceal neuroendocrine tumor",
      "appendiceal neuroendocrine tumour",
      "appendix NET",
      "appendix neuroendocrine tumor",
      "appendix neuroendocrine tumour",
      "appendix well differentiated endocrine tumor",
      "appendix well differentiated endocrine tumor/carcinoma",
      "appendix well differentiated endocrine tumour",
      "neuroendocrine neoplasm of appendix",
      "well-differentiated neuroendocrine tumor of the appendix",
      "well-differentiated neuroendocrine tumour of the appendix"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the appendix."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 16041,
      "label": "neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        4895,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025057",
          "MEDGEN:1617490",
          "NCIT:C135212",
          "UMLS:C4525742"
        ],
        "synonyms": [
          "carcinoid tumor of colon",
          "carcinoid tumour of colon",
          "colon neuroendocrine tumor",
          "colon neuroendocrine tumour",
          "neuroendocrine neoplasm of the colon",
          "NET of the colon",
          "colonic NET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the colon."
      },
      "child_count": 9,
      "reference_id": "MONDO:0015067"
    },
    {
      "id": 18543,
      "label": "epithelial tumor of the appendix",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3476,
        21434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021766",
          "MEDGEN:1842930",
          "Orphanet:423982",
          "UMLS:C5680073"
        ],
        "synonyms": [
          "appendiceal epithelial tumor",
          "appendiceal epithelial tumour",
          "vermiform appendix epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A epithelial neoplasm that involves the vermiform appendix."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018511"
    },
    {
      "id": 21454,
      "label": "appendix neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3476,
        4895
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025404",
          "MEDGEN:361887",
          "NCIT:C60709",
          "UMLS:C1879718"
        ],
        "synonyms": [
          "appendix neuroendocrine neoplasm",
          "neuroendocrine neoplasm of vermiform appendix",
          "vermiform appendix NET",
          "vermiform appendix neuroendocrine neoplasm",
          "vermiform appendix neuroendocrine tumor",
          "vermiform appendix neuroendocrine tumor, well differentiated, low or intermediate grade",
          "vermiform appendix neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the appendix. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0024501"
    }
  ],
  "children": [
    {
      "id": 7665,
      "label": "appendix neuroendocrine tumor G1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7692,
        16040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050911",
          "EFO:1000092",
          "GARD:0024288",
          "ICD9:209.11",
          "ICDO:8240/1",
          "MEDGEN:90758",
          "NCIT:C4138",
          "SCTID:253002004",
          "UMLS:C0334298"
        ],
        "synonyms": [
          "appendiceal carcinoid tumor",
          "appendiceal carcinoid tumour",
          "appendix NET G1",
          "appendix NET G1 (carcinoid)",
          "appendix carcinoid tumor",
          "appendix carcinoid tumour",
          "appendix neuroendocrine tumor G1 (carcinoid)",
          "appendix neuroendocrine tumour G1 (carcinoid)",
          "carcinoid tumor of appendix",
          "carcinoid tumor of the appendix",
          "carcinoid tumour of appendix",
          "carcinoid tumour of the appendix",
          "grade 1 neuroendocrine neoplasm of vermiform appendix",
          "vermiform appendix NET G1",
          "vermiform appendix carcinoid tumor",
          "vermiform appendix carcinoid tumor (disease)",
          "vermiform appendix carcinoid tumour",
          "vermiform appendix carcinoid tumour (disease)",
          "vermiform appendix neuroendocrine neoplasm G1",
          "vermiform appendix neuroendocrine tumor, well differentiated, low grade",
          "appendix carcinoid endocrine tumor",
          "appendix carcinoid endocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade tumor with neuroendocrine differentiation that arises from the appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006091"
    },
    {
      "id": 18190,
      "label": "classic neuroendocrine tumor of appendix",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021500",
          "MEDGEN:1843245",
          "Orphanet:329977",
          "UMLS:C5679854"
        ],
        "synonyms": [
          "classic appendiceal neuroendocrine tumor",
          "classic appendiceal neuroendocrine tumour",
          "classic appendix neuroendocrine tumor",
          "classic appendix neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Classic endocrine tumor of the appendix is a type of endocrine tumor of the appendix, seen twice as frequently in females than in males, and usually presenting before the fifth decade of life. Classic endocrine tumor of the appendix is usually asymptomatic when located in the tip of the appendix (without obstruction), but acute appendicitis is often associated."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018016"
    },
    {
      "id": 18191,
      "label": "goblet cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4255,
        5155,
        16040,
        20711
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010414",
          "ICDO:8243/3",
          "MEDGEN:60007",
          "NCIT:C3689",
          "NORD:1931",
          "ONCOTREE:GCCAP",
          "Orphanet:329984",
          "UMLS:C0205695"
        ],
        "synonyms": [
          "GCC",
          "Goblet Cell Adenocarcinoma",
          "appendix adenocarcinoid tumor",
          "appendix adenocarcinoid tumour",
          "appendix goblet cell carcinoid",
          "appendix goblet cell carcinoid tumor",
          "appendix goblet cell carcinoid tumour",
          "appendix mixed carcinoid-adenocarcinoma",
          "carcinoma of goblet cell",
          "goblet cell adenocarcinoid",
          "goblet cell carcinoid",
          "goblet cell carcinoid of appendix",
          "goblet cell carcinoid of the appendix",
          "goblet cell carcinoid tumor",
          "goblet cell carcinoid tumour",
          "goblet cell carcinoma",
          "goblet cell tumor",
          "goblet cell tumour",
          "mucinous carcinoid tumor",
          "mucinous carcinoid tumour",
          "mucinous carcinoid"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive type of endocrine tumor of the appendix presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018017"
    },
    {
      "id": 20341,
      "label": "appendix L-cell glucagon-like peptide-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6032,
        16040
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8151",
          "GARD:0025290",
          "MEDGEN:475771",
          "NCIT:C27445",
          "UMLS:C3274138"
        ],
        "synonyms": [
          "L-cell glucagon-like peptide-producing neuroendocrine tumor of vermiform appendix",
          "L-cell glucagon-like peptide-producing neuroendocrine tumour of vermiform appendix",
          "appendix L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "vermiform appendix L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "vermiform appendix L-cell glucagon-like peptide-producing neuroendocrine tumour",
          "appendiceal L-cell glucagon-like peptide producing tumor",
          "appendiceal L-cell glucagon-like peptide producing tumour",
          "appendiceal L-cell glucagon-like peptide-producing NET",
          "appendiceal L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "appendiceal L-cell glucagon-like peptide-producing neuroendocrine tumour",
          "appendix L-cell NET",
          "appendix L-cell glucagon-like peptide-producing NET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor arising from the wall of the appendix, producing glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021101"
    }
  ],
  "roots": [
    {
      "id": 16041,
      "label": "neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor"
    },
    {
      "id": 18543,
      "label": "epithelial tumor of the appendix"
    },
    {
      "id": 21454,
      "label": "appendix neuroendocrine neoplasm"
    }
  ]
}