{
  "id": 16041,
  "label": "neuroendocrine tumor of the colon, well differentiated, low or intermediate grade tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015067",
  "properties": {
    "xrefs": [
      "GARD:0025057",
      "MEDGEN:1617490",
      "NCIT:C135212",
      "UMLS:C4525742"
    ],
    "synonyms": [
      "carcinoid tumor of colon",
      "carcinoid tumour of colon",
      "colon neuroendocrine tumor",
      "colon neuroendocrine tumour",
      "neuroendocrine neoplasm of the colon",
      "NET of the colon",
      "colonic NET"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the colon."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 4895,
      "label": "colon neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4896,
        7078
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4118",
          "GARD:0019755",
          "MEDGEN:234162",
          "NCIT:C5697",
          "Orphanet:100080",
          "UMLS:C1333097",
          "icd11.foundation:144503516"
        ],
        "synonyms": [
          "colon NET",
          "colon neuroendocrine neoplasm",
          "colon neuroendocrine tumor",
          "colon neuroendocrine tumor, well differentiated, low or intermediate grade",
          "colon neuroendocrine tumour",
          "colonic neuroendocrine neoplasm",
          "colonic neuroendocrine tumour",
          "neuroendocrine neoplasm of colon",
          "neuroendocrine neoplasm of the colon",
          "neuroendocrine tumor of the colon",
          "neuroendocrine tumour of the colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the colon. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002882"
    },
    {
      "id": 21434,
      "label": "epithelial tumor of colon",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7078,
        7265
      ],
      "type_id": 0,
      "properties": {
        "synonyms": [
          "colon epithelial neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A epithelial neoplasm that involves the colon."
      },
      "child_count": 8,
      "reference_id": "MONDO:0024479"
    }
  ],
  "children": [
    {
      "id": 6032,
      "label": "colonic L-cell glucagon-like peptide producing tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6033,
        16041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7401",
          "GARD:0023878",
          "MEDGEN:475772",
          "NCIT:C27447",
          "UMLS:C3274139"
        ],
        "synonyms": [
          "L-cell glucagon-like peptide-producing neuroendocrine tumor of colon",
          "L-cell glucagon-like peptide-producing neuroendocrine tumour of colon",
          "colon L-cell glucagon-like peptide-producing NET",
          "colon L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "colon L-cell glucagon-like peptide-producing neuroendocrine tumour",
          "colonic L-cell glucagon-like peptide-producing neuroendocrine tumor",
          "colonic L-cell glucagon-like peptide-producing neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine tumor that arises from the colon and produces glucagon-like peptides. Morphologically, it is characterized by the presence of neoplastic cells forming tubular or trabecular patterns."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004210"
    },
    {
      "id": 7716,
      "label": "colon neuroendocrine tumor G1",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7723,
        16041
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000188",
          "GARD:0024313",
          "MEDGEN:234158",
          "NCIT:C5497",
          "UMLS:C1333084"
        ],
        "synonyms": [
          "carcinoid tumor of colon",
          "carcinoid tumor of the colon",
          "carcinoid tumour of colon",
          "carcinoid tumour of the colon",
          "colon NET G1",
          "colon carcinoid tumor",
          "colon carcinoid tumor (disease)",
          "colon carcinoid tumour",
          "colon carcinoid tumour (disease)",
          "colon neuroendocrine neoplasm G1",
          "colon neuroendocrine tumor G1",
          "colon neuroendocrine tumor, well differentiated, low grade",
          "colonic carcinoid tumor",
          "colonic carcinoid tumour",
          "grade 1 neuroendocrine neoplasm of colon"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the colon. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006155"
    },
    {
      "id": 16040,
      "label": "neuroendocrine tumor of the appendix, well differentiated, low or intermediate grade",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16041,
        18543,
        21454
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019754",
          "MEDGEN:474400",
          "NCIT:C96422",
          "ONCOTREE:AWDNET",
          "Orphanet:100079",
          "SCTID:725167001",
          "UMLS:C3272767",
          "icd11.foundation:1590340268"
        ],
        "synonyms": [
          "NEN of appendix",
          "appendiceal NEN",
          "appendiceal neuroendocrine neoplasm",
          "appendiceal neuroendocrine tumor",
          "appendiceal neuroendocrine tumour",
          "appendix NET",
          "appendix neuroendocrine tumor",
          "appendix neuroendocrine tumour",
          "appendix well differentiated endocrine tumor",
          "appendix well differentiated endocrine tumor/carcinoma",
          "appendix well differentiated endocrine tumour",
          "neuroendocrine neoplasm of appendix",
          "well-differentiated neuroendocrine tumor of the appendix",
          "well-differentiated neuroendocrine tumour of the appendix"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the appendix."
      },
      "child_count": 12,
      "reference_id": "MONDO:0015066"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 4895,
      "label": "colon neuroendocrine neoplasm"
    },
    {
      "id": 21434,
      "label": "epithelial tumor of colon"
    }
  ]
}