{
  "id": 16042,
  "label": "rectal neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015068",
  "properties": {
    "xrefs": [
      "GARD:0025058",
      "MEDGEN:1810164",
      "NCIT:C135213",
      "Orphanet:100081",
      "UMLS:C5554035"
    ],
    "synonyms": [
      "neuroendocrine tumor of rectum, well differentiated, low or intermediate grade",
      "rectal well differentiated neuroendocrine neoplasm",
      "rectal well-differentiated neuroendocrine neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the rectum."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 5534,
      "label": "rectum neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4896,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5777",
          "GARD:0019756",
          "MEDGEN:277576",
          "NCIT:C5698",
          "UMLS:C1335686",
          "icd11.foundation:1619951900"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of rectum",
          "neuroendocrine neoplasm of the rectum",
          "rectal neuroendocrine neoplasm",
          "rectum neuroendocrine neoplasm",
          "NET of the rectum",
          "neuroendocrine tumor of rectum",
          "neuroendocrine tumour of rectum",
          "rectal NET",
          "rectal neuroendocrine tumor",
          "rectum NET",
          "rectum neuroendocrine tumor",
          "rectum neuroendocrine tumor, well differentiated, low or intermediate grade",
          "rectum neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the rectum. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003646"
    }
  ],
  "children": [
    {
      "id": 16043,
      "label": "neuroendocrine tumor of the anal canal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5418,
        16042
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019757",
          "MEDGEN:474482",
          "NCIT:C96540",
          "Orphanet:100082",
          "UMLS:C3272849",
          "icd11.foundation:1927831331"
        ],
        "synonyms": [
          "anal canal neuroendocrine neoplasm",
          "NET of anal canal",
          "NET of the anal canal",
          "anal NET",
          "anal Neuroendocrine tumor",
          "anal Neuroendocrine tumour",
          "anal canal NET",
          "anal canal neuroendocrine tumor",
          "anal canal neuroendocrine tumour",
          "anal canal well differentiated tumor",
          "anal canal well differentiated tumor/carcinoma",
          "anal canal well differentiated tumour",
          "neuroendocrine neoplasm of the anal canal",
          "neuroendocrine tumor of anal canal",
          "neuroendocrine tumour of anal canal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the anal canal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015069"
    },
    {
      "id": 20651,
      "label": "rectal neuroendocrine tumor G1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7723,
        16042
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025332",
          "MEDGEN:233389",
          "NCIT:C5547",
          "SCTID:713306000",
          "UMLS:C1335678"
        ],
        "synonyms": [
          "carcinoid of rectum",
          "carcinoid of the rectum",
          "carcinoid tumor of rectum",
          "carcinoid tumor of the rectum",
          "carcinoid tumour of rectum",
          "carcinoid tumour of the rectum",
          "grade 1 neuroendocrine neoplasm of rectum",
          "rectal NET G1",
          "rectal carcinoid",
          "rectal carcinoid tumor",
          "rectal carcinoid tumour",
          "rectal neuroendocrine tumor G1",
          "rectum NET G1",
          "rectum carcinoid tumor",
          "rectum carcinoid tumor (disease)",
          "rectum carcinoid tumour",
          "rectum carcinoid tumour (disease)",
          "rectum neuroendocrine neoplasm G1",
          "rectum neuroendocrine tumor, well differentiated, low grade"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low grade neuroendocrine tumor (carcinoid tumor) that arises from the rectum. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021534"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 5534,
      "label": "rectum neuroendocrine neoplasm"
    }
  ]
}