{
  "id": 16044,
  "label": "laryngeal neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015070",
  "properties": {
    "xrefs": [
      "DOID:5457",
      "GARD:0019758",
      "MEDGEN:232692",
      "NCIT:C6023",
      "Orphanet:100083",
      "SCTID:707625001",
      "UMLS:C1334374",
      "icd11.foundation:1502591214"
    ],
    "synonyms": [
      "laryngeal neuroendocrine neoplasm",
      "larynx NET",
      "larynx neuroendocrine neoplasm",
      "larynx neuroendocrine tumor",
      "larynx neuroendocrine tumor, well differentiated, low or intermediate grade",
      "larynx neuroendocrine tumour",
      "neuroendocrine neoplasm of larynx",
      "neuroendocrine neoplasm of the larynx",
      "laryngeal neuroendocrine tumor",
      "laryngeal neuroendocrine tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0024623",
        "name": "otorhinolaryngologic disease"
      }
    ],
    "definition": "A benign or malignant neoplasm with neuroendocrine differentiation that arises from the larynx. This category includes paraganglioma, carcinoid tumor, small cell carcinoma, and large cell neuroendocrine carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7231,
      "label": "head and neck neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005950",
          "ICD9:239.89",
          "MEDGEN:6728",
          "NCIT:C3077",
          "ONCOTREE:HEADNECK",
          "SCTID:255055008",
          "UMLS:C0018671"
        ],
        "synonyms": [
          "craniocervical region neoplasm",
          "craniocervical region neoplasm (disease)",
          "craniocervical region tumor",
          "craniocervical region tumour",
          "head and neck neoplasm",
          "head and neck neoplasm (excluding central nervous system)",
          "head and neck tumor",
          "head and neck tumour",
          "neoplasm of craniocervical region",
          "neoplasm of head and neck",
          "neoplasm of the head and neck",
          "tumor of craniocervical region",
          "tumor of head and neck",
          "tumor of the head and neck",
          "tumour of craniocervical region",
          "tumour of head and neck",
          "tumour of the head and neck"
        ],
        "definition": "A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma."
      },
      "child_count": 37,
      "reference_id": "MONDO:0005586"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:169",
          "EFO:1001901",
          "GARD:0009316",
          "ICD9:209",
          "ICD9:209-209",
          "ICD9:239.7",
          "MEDGEN:64652",
          "MESH:D018358",
          "NCIT:C188218",
          "NCIT:C3809",
          "Orphanet:877",
          "SCTID:255046005",
          "UMLS:C0206754"
        ],
        "synonyms": [
          "APUDoma",
          "neuroendocrine neoplasm",
          "neuroendocrine tumor",
          "neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Endocrine tumors, also referred to as neuroendocrine tumors (NETs), are defined by a common phenotype which is characterized by the expression of general markers (neuron specific enolase, chromogranin, synaptophysin) and hormone secretion products. These tumors may be localized in any part of the body and are generally discovered in non-specific situations, i.e. not immediately suggestive of NETs (tests for inherited predisposition to tumors or for a clinical syndrome caused by abnormal hormone secretion)."
      },
      "child_count": 14,
      "reference_id": "MONDO:0019496"
    },
    {
      "id": 20312,
      "label": "laryngeal neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6195,
        20056
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003817",
          "MEDGEN:7271",
          "MESH:D007822",
          "NCIT:C3156",
          "SCTID:126692004",
          "UMLS:C0023055"
        ],
        "synonyms": [
          "laryngeal neoplasm",
          "laryngeal tumor",
          "laryngeal tumour",
          "larynx neoplasm",
          "larynx neoplasm (disease)",
          "larynx tumor",
          "larynx tumour",
          "neoplasm of larynx",
          "neoplasm of the larynx",
          "tumor of larynx",
          "tumor of the larynx",
          "tumour of larynx",
          "tumour of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm involving the larynx."
      },
      "child_count": 12,
      "reference_id": "MONDO:0021071"
    },
    {
      "id": 21538,
      "label": "otorhinolaryngologic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:478.19",
          "MEDGEN:583054",
          "MESH:D010038",
          "NANDO:1100015",
          "NCIT:C118420",
          "SCTID:232208008",
          "UMLS:C0395797"
        ],
        "synonyms": [
          "ear, nose and throat disorder",
          "ear, nose or throat disorder",
          "ear/nose/throat disease",
          "otolaryngologic disorder",
          "otorhinolaryngologic disease",
          "ENT disease",
          "ENT diseases",
          "disease, ENT",
          "disease, otolaryngologic",
          "disease, otolaryngological",
          "disease, otorhinolaryngologic",
          "disease, otorhinolaryngological",
          "diseases, ENT",
          "diseases, otolaryngologic",
          "diseases, otolaryngological",
          "diseases, otorhinolaryngologic",
          "diseases, otorhinolaryngological",
          "otolaryngologic disease",
          "otolaryngologic diseases",
          "otolaryngological disease",
          "otolaryngological diseases",
          "otorhinolaryngological disease",
          "otorhinolaryngological diseases"
        ],
        "categories": [
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases."
      },
      "child_count": 40,
      "reference_id": "MONDO:0024623"
    }
  ],
  "children": [
    {
      "id": 7809,
      "label": "laryngeal small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        4185,
        4457,
        16044
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7144",
          "EFO:1000320",
          "GARD:0024352",
          "MEDGEN:233611",
          "NCIT:C6025",
          "UMLS:C1334378"
        ],
        "synonyms": [
          "laryngeal small cell carcinoma",
          "laryngeal throat small cell cancer",
          "larynx small cell carcinoma",
          "small cell carcinoma of larynx",
          "small cell carcinoma of the larynx"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0024623",
            "name": "otorhinolaryngologic disease"
          }
        ],
        "definition": "A rare carcinoma that arises from the larynx. It is characterized by the presence of small neuroendocrine cells. It metastasizes early and has an aggressive clinical course."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006265"
    }
  ],
  "roots": [
    {
      "id": 7231,
      "label": "head and neck neoplasm"
    },
    {
      "id": 19314,
      "label": "neuroendocrine neoplasm"
    },
    {
      "id": 20312,
      "label": "laryngeal neoplasm"
    },
    {
      "id": 21538,
      "label": "otorhinolaryngologic disease"
    }
  ]
}