{
  "id": 16046,
  "label": "liver neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015072",
  "properties": {
    "xrefs": [
      "GARD:0019760",
      "MEDGEN:474664",
      "NCIT:C96787",
      "Orphanet:100085",
      "SCTID:716652006",
      "UMLS:C3273031"
    ],
    "synonyms": [
      "HNEC",
      "PHNEC",
      "hepatic neuroendocrine carcinoma",
      "liver neuroendocrine cancer",
      "liver neuroendocrine carcinoma",
      "neuroendocrine carcinoma of liver",
      "primary hepatic neuroendocrine carcinoma",
      "primary liver neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An extremely rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4735,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021786",
          "MEDGEN:78921",
          "NCIT:C7927",
          "ONCOTREE:HCCIHCH",
          "Orphanet:424936",
          "UMLS:C0279000"
        ],
        "synonyms": [
          "cancer of liver",
          "cancer of liver and intrahepatic biliary tract",
          "cancer of the liver",
          "cancer of the liver and intrahepatic biliary tract",
          "carcinoma of liver",
          "hepatic cancer",
          "liver and intrahepatic bile duct cancer",
          "liver cancer",
          "liver carcinoma",
          "liver/hepatobiliary cancer",
          "carcinoma of liver and IBT",
          "liver and intrahepatic bile duct carcinoma",
          "liver and intrahepatic biliary tract cancer",
          "liver and intrahepatic biliary tract carcinoma",
          "primary liver carcinoma",
          "hepatocellular carcinoma plus intrahepatic cholangiocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma."
      },
      "child_count": 14,
      "reference_id": "MONDO:0018531"
    },
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        19314,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002437",
          "MEDGEN:232237",
          "MESH:C535650",
          "NCIT:C27721",
          "Orphanet:100092",
          "UMLS:C1333799"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system NET",
          "alimentary part of gastrointestinal system neuroendocrine neoplasm",
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "carcinoid tumor of digestive system",
          "carcinoid tumour of digestive system",
          "digestive system NET",
          "digestive system neuroendocrine neoplasm",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumor, well differentiated, low or intermediate grade",
          "digestive system neuroendocrine tumour",
          "gastro-enteropancreatic neuroendocrine tumor",
          "gastro-enteropancreatic neuroendocrine tumour",
          "gastroenteropancreatic endocrine tumor",
          "gastroenteropancreatic endocrine tumour",
          "gastroenteropancreatic neuroendocrine neoplasm",
          "gastrointestinal neuroendocrine neoplasm",
          "gastrointestinal system neuroendocrine neoplasm",
          "neuroendocrine neoplasm of alimentary part of gastrointestinal system",
          "neuroendocrine neoplasm of digestive system",
          "GEP tumors",
          "GEP tumours",
          "GEP-NEN",
          "GEP-NET",
          "carcinoid tumor",
          "carcinoid tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation arising from the digestive system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas)."
      },
      "child_count": 21,
      "reference_id": "MONDO:0024503"
    }
  ],
  "children": [
    {
      "id": 5590,
      "label": "extrahepatic bile duct small cell adenocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        4714,
        16046
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5926",
          "GARD:0023628",
          "MEDGEN:277648",
          "NCIT:C5845",
          "UMLS:C1335979"
        ],
        "synonyms": [
          "Oat cell carcinoma of extrahepatic bile duct",
          "Oat cell carcinoma of the extrahepatic bile duct",
          "Oat cell extrahepatic bile duct carcinoma",
          "extrahepatic bile duct small cell NEC",
          "extrahepatic bile duct small cell neuroendocrine carcinoma",
          "small cell adenocarcinoma of extrahepatic bile duct",
          "small cell adenocarcinoma of the extrahepatic bile duct",
          "small cell extrahepatic bile duct carcinoma",
          "small cell extrahepatic bile duct neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It is characterized by the presence of malignant small cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003708"
    },
    {
      "id": 5949,
      "label": "ampulla of vater small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        16046,
        17870,
        21453
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7136",
          "GARD:0023833",
          "MEDGEN:233974",
          "NCIT:C6655",
          "UMLS:C1332250"
        ],
        "synonyms": [
          "ampulla of Vater small cell NEC",
          "ampulla of Vater small cell carcinoma",
          "ampulla of Vater small cell neuroendocrine carcinoma",
          "ampullary small cell carcinoma",
          "hepatopancreatic ampulla small cell carcinoma",
          "small cell neuroendocrine carcinoma of the ampullary region"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive neuroendocrine carcinoma arising from the ampulla of Vater and the periampullary region. Morphologically, it is characterized by the presence of small malignant cells, necrosis, and a high mitotic rate. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004117"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 18551,
      "label": "carcinoma of liver and intrahepatic biliary tract"
    },
    {
      "id": 21456,
      "label": "digestive system neuroendocrine neoplasm"
    }
  ]
}