{
  "id": 16049,
  "label": "thyroid gland carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015075",
  "properties": {
    "xrefs": [
      "DOID:3963",
      "EFO:0002892",
      "GARD:0019763",
      "HP:0002890",
      "MEDGEN:107811",
      "MedDRA:10007476",
      "NANDO:2200074",
      "NCIT:C4815",
      "Orphanet:100088",
      "SCTID:448216007",
      "UMLS:C0549473"
    ],
    "synonyms": [
      "cancer of the thyroid",
      "cancer of thyroid",
      "head and neck cancer, thyroid",
      "thyroid cancer",
      "thyroid gland cancer",
      "carcinoma of the thyroid",
      "carcinoma of the thyroid gland",
      "carcinoma of thyroid",
      "carcinoma of thyroid gland",
      "thyroid carcinoma",
      "thyroid gland carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 4245,
      "label": "thyroid cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16048,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1781",
          "ICD10CM:C73",
          "ICD9:193",
          "MEDGEN:2869",
          "NANDO:2200074",
          "NCIT:C7510",
          "SCTID:363478007",
          "UMLS:C0007115",
          "icd11.foundation:447433352"
        ],
        "synonyms": [
          "neoplasm of thyroid gland",
          "thyroid gland neoplasm",
          "cancer of thyroid gland",
          "malignant neoplasm of the thyroid",
          "malignant neoplasm of the thyroid gland",
          "malignant neoplasm of thyroid",
          "malignant neoplasm of thyroid gland",
          "malignant thyroid gland neoplasm",
          "malignant thyroid gland tumor",
          "malignant thyroid gland tumour",
          "malignant thyroid neoplasm",
          "malignant thyroid tumor",
          "malignant thyroid tumour",
          "malignant tumor of the thyroid",
          "malignant tumor of the thyroid gland",
          "malignant tumor of thyroid",
          "malignant tumor of thyroid gland",
          "malignant tumour of the thyroid",
          "malignant tumour of the thyroid gland",
          "malignant tumour of thyroid",
          "malignant tumour of thyroid gland",
          "thyroid gland cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the thyroid gland"
      },
      "child_count": 6,
      "reference_id": "MONDO:0002108"
    },
    {
      "id": 6734,
      "label": "carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2000-1867",
          "DOID:305",
          "EFO:0000313",
          "ICDO:8010/3",
          "ICDO:8011/3",
          "MEDGEN:2867",
          "MESH:D002277",
          "NCIT:C2916",
          "SCTID:722688002",
          "UMLS:C0007097"
        ],
        "synonyms": [
          "epithelioma",
          "Other carcinoma",
          "carcinoma",
          "carcinoma, malignant",
          "epithelial carcinoma",
          "epithelioma malignant",
          "malignant epithelial neoplasm",
          "malignant epithelial tumor",
          "malignant epithelial tumour",
          "malignant epithelioma"
        ],
        "definition": "A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas. Morphologically, the malignant epithelial cells may display abnormal mitotic figures, anaplasia, and necrosis. Carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Carcinomas invade the surrounding tissues and tend to metastasize to other anatomic sites. Lung carcinoma, skin carcinoma, breast carcinoma, colon carcinoma, and prostate carcinoma are the most frequently seen carcinomas."
      },
      "child_count": 98,
      "reference_id": "MONDO:0004993"
    }
  ],
  "children": [
    {
      "id": 7966,
      "label": "thyroid gland spindle cell tumor with thymus-like differentiation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050923",
          "DOID:0081461",
          "EFO:1000593",
          "GARD:0024422",
          "ICDO:8588/3",
          "MEDGEN:220415",
          "NCIT:C46105",
          "UMLS:C1266099"
        ],
        "synonyms": [
          "SETTLE",
          "settle",
          "spindle epithelial tumor with thymus-like differentiation tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, slow growing, primary carcinoma of the thyroid gland characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells. A small number of cases are composed exclusively of spindle epithelial cells or glandular cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006466"
    },
    {
      "id": 7967,
      "label": "thyroid gland squamous cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6823,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000594",
          "GARD:0024423",
          "MEDGEN:328050",
          "NCIT:C46008",
          "UMLS:C1710177"
        ],
        "synonyms": [
          "squamous cell thyroid gland carcinoma",
          "thyroid gland squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rapidly growing primary carcinoma of the thyroid gland composed of malignant squamous cells. The clinical course is usually aggressive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006467"
    },
    {
      "id": 7968,
      "label": "thyroid gland undifferentiated (anaplastic) carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6943,
        7257,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080522",
          "EFO:1000595",
          "GARD:0000664",
          "HP:0011779",
          "MEDGEN:116064",
          "MESH:D065646",
          "MedDRA:10002240",
          "NCIT:C3878",
          "ONCOTREE:THAP",
          "Orphanet:142",
          "SCTID:255031003",
          "UMLS:C0238461",
          "icd11.foundation:320540024"
        ],
        "synonyms": [
          "Dedifferentiated thyroid gland carcinoma",
          "anaplastic carcinoma of the thyroid",
          "anaplastic carcinoma of the thyroid gland",
          "anaplastic carcinoma of thyroid",
          "anaplastic carcinoma of thyroid gland",
          "anaplastic thyroid cancer",
          "anaplastic thyroid carcinoma",
          "anaplastic thyroid gland carcinoma",
          "metaplastic thyroid gland carcinoma",
          "pleomorphic thyroid gland carcinoma",
          "sarcomatoid thyroid gland carcinoma",
          "thyroid gland carcinosarcoma",
          "thyroid gland undifferentiated (anaplastic) carcinoma",
          "thyroid gland undifferentiated carcinoma",
          "undifferentiated (anaplastic) thyroid gland cancer",
          "undifferentiated (anaplastic) thyroid gland carcinoma",
          "undifferentiated carcinoma of the thyroid",
          "undifferentiated carcinoma of the thyroid gland",
          "undifferentiated carcinoma of thyroid",
          "undifferentiated carcinoma of thyroid gland",
          "undifferentiated thyroid carcinoma",
          "undifferentiated thyroid gland carcinoma",
          "undifferentiated thyroid tumor",
          "undifferentiated thyroid tumour",
          "THAP",
          "thyroid cancer, anaplastic",
          "thyroid carcinoma, anaplastic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006468"
    },
    {
      "id": 16290,
      "label": "differentiated thyroid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080525",
          "EFO:1002017",
          "GARD:0012027",
          "MEDGEN:277876",
          "NCIT:C7153",
          "ONCOTREE:WDTC",
          "Orphanet:146",
          "UMLS:C1337013"
        ],
        "synonyms": [
          "differentiated thyroid cancer",
          "differentiated thyroid carcinoma",
          "differentiated thyroid gland cancer",
          "differentiated thyroid gland carcinoma",
          "papillary or follicular thyroid carcinoma",
          "thyroid gland differentiated carcinoma",
          "thyroid gland well differentiated carcinoma",
          "well differentiated thyroid carcinoma",
          "well differentiated thyroid gland carcinoma",
          "well-differentiated thyroid cancer",
          "well-differentiated thyroid carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Differentiated thyroid carcinoma (DTC), also known as papillary or follicular thyroid carcinoma, is a slow-growing malignancy usually presenting in adults as an asymptomatic thyroid mass."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015447"
    },
    {
      "id": 18106,
      "label": "familial nonmedullary thyroid carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021421",
          "MEDGEN:502247",
          "OMIMPS:188550",
          "Orphanet:319494",
          "UMLS:C3501843"
        ],
        "synonyms": [
          "thyroid cancer, nonmedullary"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Familial nonmedullary thyroid carcinoma (fNMTC) is a rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting."
      },
      "child_count": 6,
      "reference_id": "MONDO:0017896"
    },
    {
      "id": 18918,
      "label": "multiple endocrine neoplasia type 2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16049,
        17512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003830",
          "ICD9:194.8",
          "ICD9:258.02",
          "MEDGEN:887211",
          "MedDRA:10028191",
          "NANDO:2200406",
          "NCIT:C123329",
          "NORD:1467",
          "Orphanet:653",
          "SCTID:61808009",
          "UMLS:C4048306",
          "icd11.foundation:1837913809"
        ],
        "synonyms": [
          "MEN2",
          "multiple endocrine neoplasia type 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Multiple endocrine neoplasia type 2 (MEN2) is a multiple endocrine neoplasia, a polyglandular cancer syndrome characterized by the occurrence of medullary thyroid carcinoma (MTC), pheochromocytoma (PCC), in one variant, primary hyperparathyroidism (PHPT). There are three forms: MEN2A, MEN2B, and familial medullary thyroid carcinoma (FMTC)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0019003"
    },
    {
      "id": 21537,
      "label": "thyroid gland adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712,
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080524",
          "GARD:0025440",
          "MEDGEN:309935",
          "NCIT:C27380",
          "UMLS:C1704228"
        ],
        "synonyms": [
          "thyroid adenocarcinoma",
          "thyroid gland adenocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0024622"
    },
    {
      "id": 26015,
      "label": "intrathyroid thymic carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081457",
          "GARD:0027155",
          "MEDGEN:316474",
          "UMLS:C1704613"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid gland carcinoma composed of groups of carcinoma cells with thymic epithelial differentiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0971033"
    },
    {
      "id": 26016,
      "label": "thyroid gland cribriform morular carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081458",
          "GARD:0027156",
          "MEDGEN:927266",
          "UMLS:C4289734"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid gland carcinoma that is characterized by the presence of cribriform, trabecular, follicular, papillary, and solid growth patterns and squamoid morulae formation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0971034"
    },
    {
      "id": 26017,
      "label": "thyroid gland mixed medullary and follicular cell-derived carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081459",
          "GARD:0027157",
          "MEDGEN:1815194",
          "UMLS:C5706289"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid gland carcinoma containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and follicular cell-derived carcinoma component that is immunohistochemically positive for thyroglobulin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0971035"
    },
    {
      "id": 26018,
      "label": "thyroid gland mucinous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16049
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081460",
          "GARD:0027158",
          "MEDGEN:1661824",
          "UMLS:C4744698"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A thyroid gland carcinoma that is characterized by the presence of clusters of malignant epithelial cells associated with abundant extracellular mucin deposition."
      },
      "child_count": 0,
      "reference_id": "MONDO:0971036"
    }
  ],
  "roots": [
    {
      "id": 4245,
      "label": "thyroid cancer"
    },
    {
      "id": 6734,
      "label": "carcinoma"
    }
  ]
}