{
  "id": 16151,
  "label": "medullary sponge kidney",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015268",
  "properties": {
    "xrefs": [
      "GARD:0000232",
      "ICD9:753.17",
      "MEDGEN:5970",
      "MESH:D007691",
      "MedDRA:10027104",
      "NANDO:2200173",
      "NCIT:C34751",
      "NORD:1421",
      "Orphanet:1309",
      "SCTID:236443009",
      "UMLS:C0022681",
      "icd11.foundation:1723148250"
    ],
    "synonyms": [
      "Cacchi-Ricci disease",
      "MSK",
      "Precalicial canalicular ectasia",
      "Cacchi Ricci disease",
      "Cacchi-Ricci syndrome",
      "Precalyceal canalicular ectasia",
      "cystic dilatation of renal collecting tubes",
      "sponge kidney"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Medullary sponge kidney (MSK) is a birth defect of the tubules - tiny tubes inside the kidneys. In a normal kidney, urine flows through these tubules as it is being formed. In MSK, tiny sacs called cysts form in the medulla (the inner part of the kidney), creating a sponge-like appearance. The cysts keep urine from flowing freely through the tubules. MSK is present at birth but symptoms typically do not occur until adolescence or adulthood. Problems caused by MSK include blood in the urine, kidney stones, and urinary tract infections. MSK rarely leads to more serious problems, such as total kidney failure. There is no cure for this condition, so treatment is aimed at removing kidney stones and treating urinary tract infections with antibiotics."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4553,
      "label": "cystic kidney disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6948
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2975",
          "EFO:0008615",
          "ICD10CM:Q61",
          "ICD10WHO:Q61",
          "MEDGEN:854361",
          "MESH:D052177",
          "NANDO:2200172",
          "NCIT:C34750",
          "SCTID:722223000",
          "UMLS:C3887499"
        ],
        "synonyms": [
          "cystic renal disease",
          "kidney cyst"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A congenital or acquired kidney disorder characterized by the presence of renal cysts."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002473"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4553,
      "label": "cystic kidney disease"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}