{
  "id": 16183,
  "label": "macular amyloidosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015303",
  "properties": {
    "xrefs": [
      "GARD:0019885",
      "MEDGEN:1372504",
      "Orphanet:137814",
      "UMLS:C0544839",
      "icd11.foundation:1192013809"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      }
    ],
    "definition": "Macular amyloidosis (MA) is a rare chronic form of cutaneous amyloidosis, a skin disease characterized by the accumulation of amyloid deposits in the dermis, clinically characterized by pruritic hyperkeratotic gray-brown macules that give a rippled or reticulated pattern of pigmentation usually in the upper back and extensor sites of arms, forearms and legs, and histologically by the deposition of amyloid in the upper dermis and close to the basal cell layer of the epidermis. MA is commonly associated with other skin diseases, such as atopic dermatitis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16181,
      "label": "primary cutaneous amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18960,
        20387
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050639",
          "GARD:0000132",
          "MEDGEN:120635",
          "MESH:C562642",
          "MedDRA:10011659",
          "NCIT:C199391",
          "Orphanet:137807",
          "SCTID:282834007",
          "UMLS:C0268397"
        ],
        "synonyms": [
          "primary localised cutaneous amyloidosis",
          "primary localized cutaneous amyloidosis",
          "PLCA",
          "familial primary localised cutaneous amyloidosis",
          "familial primary localized cutaneous amyloidosis",
          "amyloidosis IX",
          "amyloidosis familial cutaneous lichen",
          "amyloidosis, primary localised cutaneous",
          "amyloidosis, primary localized cutaneous",
          "lichen amyloidosis familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "Cutaneous amyloidosis refers to a variety of skin diseases characterized histologically by the extracellular accumulation of amyloid deposits in the dermis. Rare forms include lichen amyloidosus, X-linked reticulate pigmentary disorder, primary localized cutaneous nodular amyloidosis, and macular amyloidosis."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015301"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16181,
      "label": "primary cutaneous amyloidosis"
    }
  ]
}