{
  "id": 16200,
  "label": "isolated craniosynostosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015337",
  "properties": {
    "xrefs": [
      "MEDGEN:1863457",
      "NANDO:2200843",
      "Orphanet:139390",
      "UMLS:C5848302"
    ],
    "synonyms": [
      "nonsyndromic craniosynostosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "A craniosynostosis that is not part of a larger syndrome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 16310,
      "label": "craniosynostosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3632,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2340",
          "GARD:0006209",
          "ICD10CM:Q75.0",
          "MEDGEN:1163",
          "MESH:D003398",
          "MedDRA:10048907",
          "MedDRA:10049889",
          "NANDO:2100227",
          "NCIT:C84655",
          "OMIMPS:123100",
          "Orphanet:1531",
          "UMLS:C0010278",
          "icd11.foundation:458033798"
        ],
        "synonyms": [
          "craniosynostosis syndrome",
          "premature closure of cranial sutures",
          "CSO"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Craniosynostosis is defined as the premature fusion of one or more cranial sutures leading to secondary distortion of skull shape resulting in skull deformities with a variable presentation. Craniosynostosis may occur in an isolated setting or as part of a syndrome."
      },
      "child_count": 58,
      "reference_id": "MONDO:0015469"
    }
  ],
  "children": [
    {
      "id": 9197,
      "label": "isolated cloverleaf skull syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0003115",
          "MEDGEN:98141",
          "MESH:C536884",
          "OMIM:148800",
          "Orphanet:2343",
          "SCTID:254022009",
          "UMLS:C0432126"
        ],
        "synonyms": [
          "isolated cloverleaf skull syndrome",
          "KLEEBLATTSCHAEDEL",
          "Kleeblattschadel",
          "Kleeblattschaedel deformity syndrome",
          "Kleeblattschaedel syndrome",
          "Kleeblattschaedel-deformity syndrome",
          "cloverleaf skull",
          "cloverleaf skull syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Isolated cloverleaf skull syndrome is a form of craniosynostosis involving multiple sutures (coronal, lambdoidal, sagittal and metopic) characterized by a trilobular skull of varying severity (frontal towering and bossing, temporal bulging and a flat posterior skull), dysmorphic features (downslanting palpebral fissures, midface hypoplasia, and extreme proptosis) and that is complicated by hydrocephalus, cerebral venous hypertension, developmental delay/intellectual disability and hind brain herniation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007861"
    },
    {
      "id": 18228,
      "label": "isolated trigonocephaly",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2748,
        16200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016626",
          "MEDGEN:1812049",
          "NANDO:2201305",
          "OMIMPS:190440",
          "Orphanet:3366",
          "UMLS:C5575700"
        ],
        "synonyms": [
          "non-syndromic metopic craniosynostosis",
          "nonsyndromic trigonocephaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Isolated trigonocephaly is a nonsyndromic form of craniosynostosis characterized by the premature fusion of the metopic suture."
      },
      "child_count": 4,
      "reference_id": "MONDO:0018065"
    },
    {
      "id": 18891,
      "label": "isolated oxycephaly",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025134",
          "MEDGEN:1726910",
          "Orphanet:63440",
          "SCTID:48069004",
          "UMLS:C5399823"
        ],
        "synonyms": [
          "acrocephaly",
          "hypsicephaly",
          "hypsocephaly",
          "pyrgocephaly",
          "turricephaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Isolated oxycephaly is a late-appearing form of nonsyndromic craniosynostosis characterized by premature fusion of both the coronal and sagittal sutures, and, in some cases, of the lambdoid sutures. Compensatory growth in the region of the anterior fontanel results in a pointed or cone-shaped skull."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018971"
    },
    {
      "id": 25115,
      "label": "non-syndromic unisutural craniosynostosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16200
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022469",
          "MEDGEN:1843281",
          "Orphanet:620096",
          "UMLS:C5680403"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0850072"
    }
  ],
  "roots": [
    {
      "id": 16310,
      "label": "craniosynostosis"
    }
  ]
}