{
  "id": 16203,
  "label": "drug rash with eosinophilia and systemic symptoms",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015340",
  "properties": {
    "xrefs": [
      "GARD:0013629",
      "ICD10CM:D72.12",
      "MEDGEN:762193",
      "MESH:D063926",
      "MedDRA:10058919",
      "NCIT:C112208",
      "Orphanet:139402",
      "SCTID:702809001",
      "UMLS:C3541994",
      "icd11.foundation:516577496"
    ],
    "synonyms": [
      "DHS",
      "DRESS",
      "DRESS syndrome",
      "Drug hypersensitivity syndrome",
      "Drug reaction with eosinophilia and Systemic symptoms",
      "dress",
      "drug reaction eosinophilic systemic syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      }
    ],
    "definition": "DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a hypersensitivity reaction characterized by a generalized skin rash, fever, eosinophilia, lymphocytosis and visceral involvement (hepatitis, nephritis, pneumonitis, pericarditis and myocarditis) and, in some patients, reactivation of human herpes virus 6."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 7148,
      "label": "urticaria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4496
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1555",
          "EFO:0005531",
          "HP:0001025",
          "ICD10CM:L50",
          "ICD10WHO:L50",
          "ICD9:708",
          "ICD9:708.8",
          "ICD9:708.9",
          "MEDGEN:22587",
          "MESH:D014581",
          "NCIT:C3432",
          "SCTID:126485001",
          "UMLS:C0042109"
        ],
        "synonyms": [
          "hives",
          "urticaria",
          "urticaria (disease)",
          "Urticarias"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress."
      },
      "child_count": 14,
      "reference_id": "MONDO:0005492"
    },
    {
      "id": 7238,
      "label": "severe cutaneous adverse reaction",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0006346",
          "MEDGEN:1843455",
          "MESH:D002921",
          "MedDRA:20000020",
          "UMLS:C5554042"
        ],
        "synonyms": [
          "SCAR"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A group of skin disorders including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE)."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005594"
    },
    {
      "id": 17704,
      "label": "toxic dermatosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021171",
          "MEDGEN:1842825",
          "Orphanet:293815",
          "UMLS:C5680999"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ]
      },
      "child_count": 5,
      "reference_id": "MONDO:0017396"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 7148,
      "label": "urticaria"
    },
    {
      "id": 7238,
      "label": "severe cutaneous adverse reaction"
    },
    {
      "id": 17704,
      "label": "toxic dermatosis"
    }
  ]
}