{
  "id": 16323,
  "label": "immune complex mediated vasculitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015491",
  "properties": {
    "xrefs": [
      "GARD:0019984",
      "MEDGEN:1842565",
      "Orphanet:156149",
      "UMLS:C5680655"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 18813,
      "label": "vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:865",
          "EFO:0006803",
          "GARD:0018844",
          "MEDGEN:12054",
          "MESH:D014657",
          "MedDRA:10036023",
          "MedDRA:10047115",
          "NCIT:C26912",
          "Orphanet:52759",
          "SCTID:31996006",
          "UMLS:C0042384",
          "Wikipedia:Vasculitis",
          "icd11.foundation:572581721"
        ],
        "synonyms": [
          "systemic vasculitis",
          "angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Vasculitis represents a clinically heterogenous group of diseases of multifactorial etiology characterized by inflammation of either large-sized vessels (large-vessel vasculitis, e.g. Giant-cell arteritis and Takayasu arteritis), medium-sized vessels (medium-vessel vasculitis e.g. polyarteritis nodosa and Kawasaki disease), or small-sized vessels (small-vessel vasculitis, e.g. granulomatosis with polyangiitis, microscopic polyangiitis, immunoglobulin A vasculitis, and cutaneous leukocytoclastic angiitis). Vasculitis occurs at any age, may be acute or chronic, and manifests with general symptoms such as fever, weight loss and fatigue, as well as more specific clinical signs depending on the type of vessels and organs affected. The degree of severity is variable, ranging from life or sight threatening disease (e.g. Behcet disease) to relatively minor skin disease."
      },
      "child_count": 36,
      "reference_id": "MONDO:0018882"
    }
  ],
  "children": [
    {
      "id": 8798,
      "label": "Cryoglobulinemic vasculitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16323
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006386",
          "ICD9:273.2",
          "MEDGEN:343814",
          "MESH:C565141",
          "MedDRA:10027756",
          "NORD:1452",
          "OMIM:123550",
          "Orphanet:91138",
          "SCTID:190815001",
          "UMLS:C1852456",
          "icd11.foundation:55133785"
        ],
        "synonyms": [
          "MC",
          "Mixed Cryoglobulinemia",
          "essential cryoglobulinemia",
          "essential mixed cryoglobulinemia",
          "mixed cryoglobulinemia",
          "primary cryoglobulinemia",
          "Meltzer syndrome",
          "cryoglobulinemia, familial mixed",
          "familial mixed cryoglobulinemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Mixed cryoglobulinemia (MC) is a rare multisystem disease characterized by the presence of circulating cryoprecipitable immune complexes in the serum, manifested clinically by a classical triad of purpura, weakness and arthralgia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0007407"
    },
    {
      "id": 18357,
      "label": "hypocomplementemic urticarial vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16323
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006725",
          "MEDGEN:83360",
          "Orphanet:36412",
          "SCTID:239945009",
          "UMLS:C0343206",
          "icd11.foundation:629572966"
        ],
        "synonyms": [
          "Mac Duffie hypocomplementemic urticarial vasculitis",
          "Mac Duffie syndrome",
          "McDuffie hypocomplementemic urticarial vasculitis",
          "McDuffie syndrome",
          "anti-C1q vasculitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Hypocomplementemic urticarial vasculitis (HUV) is an immune complex-mediated small vessel vasculitis characterized by urticaria and hypocomplementemia (low C1q with or without low C3 and C4), and usually associated with circulating anti-C1q autoantibodies. Arthritis, pulmonary disease, ocular inflammation, and glomerulonephritis are common systemic manifestations."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018227"
    },
    {
      "id": 19042,
      "label": "immunoglobulin A vasculitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        8242,
        16323,
        24822
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11123",
          "GARD:0008204",
          "ICD10CM:D69.0",
          "ICD9:287.0",
          "MEDGEN:48265",
          "MESH:D011695",
          "NCIT:C34963",
          "Orphanet:761",
          "SCTID:191306005",
          "SCTID:86074002",
          "UMLS:C0034152",
          "icd11.foundation:1629105375"
        ],
        "synonyms": [
          "HSP",
          "IgA vasculitis",
          "Schoenlein-Henoch purpura",
          "allergic purpura",
          "anaphylactoid purpura",
          "purpura rheumatica",
          "rheumatoid purpura",
          "Henoch Schonlein purpura",
          "purpura, Schonlein-Henoch",
          "vascular purpura"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A systemic IgA vasculitis that affects small vessels. It is characterized by skin purpura, arthritis, and abdominal and/or renal involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019167"
    },
    {
      "id": 19326,
      "label": "cutaneous leukocytoclastic angiitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16323
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007851",
          "MEDGEN:881641",
          "NCIT:C122919",
          "Orphanet:889",
          "SCTID:718217000",
          "UMLS:C4049638",
          "icd11.foundation:247535295",
          "icd11.foundation:71458216"
        ],
        "synonyms": [
          "cutaneous hypersensitivity vasculitis",
          "cutaneous leukocytoclastic vasculitis",
          "cutaneous small vessel vasculitis",
          "cutaneous small-vessel vasculitis",
          "hypersensitivity angiitis",
          "leukocytoclastic angiitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Cutaneous leukocytoclastic angiitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs. Systemic symptoms including fever, cough, hemoptysis, sinusitis, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, hematochezia, paresthesia, weakness, and hematuria may be observed. Skin biopsy reveals exudates rich in neutrophils, endothelial damage, fibrin deposition, and leukocytoclasis in postcapillary venules of small vessels. Cutaneous leukocytoclastic angiitis can be idiopathic (in up to 50% of cases) or secondary to infections, medications (such as antituberculosis medication), collagen vascular diseases, or neoplasms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019509"
    },
    {
      "id": 19336,
      "label": "erythema elevatum diutinum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16323
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060567",
          "GARD:0008653",
          "ICD10CM:L95.1",
          "ICD9:695.89",
          "MEDGEN:75517",
          "MESH:C535509",
          "MedDRA:10056968",
          "Orphanet:90000",
          "SCTID:58872001",
          "UMLS:C0263398",
          "icd11.foundation:754210950"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Erythema elevatum diutinum (EED) is a distinctive form of chronic cutaneous vasculitis, belonging to the group of the neutrophilic dermatoses."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019526"
    }
  ],
  "roots": [
    {
      "id": 18813,
      "label": "vasculitis"
    }
  ]
}