{
  "id": 16341,
  "label": "cold-induced sweating syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015526",
  "properties": {
    "xrefs": [
      "DOID:0060294",
      "GARD:0016983",
      "MEDGEN:321950",
      "OMIMPS:272430",
      "Orphanet:157820",
      "SCTID:702363009",
      "UMLS:C1832409",
      "icd11.foundation:1884908195"
    ],
    "synonyms": [
      "CISS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Cold-induced sweating syndrome (CISS) is characterized by profuse sweating (involving the chest, face, arms and trunk) induced by cold ambient temperature."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 18479,
      "label": "cold-induced sweating syndrome - hyperthermia spectrum",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16223
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021708",
          "MEDGEN:1842440",
          "Orphanet:401993",
          "UMLS:C5681139"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0018431"
    }
  ],
  "children": [
    {
      "id": 11278,
      "label": "Cold-induced sweating syndrome 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16341
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080329",
          "GARD:0001611",
          "MEDGEN:338577",
          "MESH:C536214",
          "OMIM:272430",
          "OMIM:601378",
          "Orphanet:1545",
          "SCTID:725097006",
          "UMLS:C1848947"
        ],
        "synonyms": [
          "Crisponi syndrome",
          "cold-induced sweating syndrome type 1",
          "CISS1",
          "CRISPONI/cold-induced sweating syndrome 1",
          "Crisponi/cold-induced sweating syndrome 1",
          "Sohar-Crisponi syndrome",
          "cold-induced sweating syndrome 1",
          "muscle contractions, Tetanoform, with characteristic face, camptodactyly, hyperthermia, and sudden death"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Crisponi syndrome (CS) is a severe disorder characterized by muscular contractions at birth, intermittent hyperthermia, facial abnormalities and camptodactyly."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010091"
    },
    {
      "id": 13516,
      "label": "cold-induced sweating syndrome 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16341
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080330",
          "GARD:0018277",
          "MEDGEN:342816",
          "MESH:C564791",
          "OMIM:610313",
          "UMLS:C1853198"
        ],
        "synonyms": [
          "CLCF1 cold-induced sweating syndrome",
          "cold-induced sweating syndrome 2",
          "cold-induced sweating syndrome caused by mutation in CLCF1",
          "cold-induced sweating syndrome type 2",
          "CISS2",
          "CRISPONI/cold-induced sweating syndrome 2",
          "Crisponi/cold-induced sweating syndrome 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any cold-induced sweating syndrome in which the cause of the disease is a mutation in the CLCF1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012467"
    },
    {
      "id": 15871,
      "label": "PERCHING syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16341
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080331",
          "GARD:0018278",
          "MEDGEN:934709",
          "OMIM:617055",
          "Orphanet:603684",
          "UMLS:C4310742"
        ],
        "synonyms": [
          "CISS3",
          "KLHL7 cold-induced sweating syndrome",
          "KLHL7-related bohring-opitz-like/cold-induced sweating-like overlap syndrome",
          "PERCHING",
          "cold-induced sweating syndrome caused by mutation in KLHL7",
          "cold-induced sweating syndrome type 3",
          "CRISPONI/cold-induced sweating syndrome 3",
          "Crisponi/cold-induced sweating syndrome 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any cold-induced sweating syndrome in which the cause of the disease is a mutation in the KLHL7 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014890"
    }
  ],
  "roots": [
    {
      "id": 18479,
      "label": "cold-induced sweating syndrome - hyperthermia spectrum"
    }
  ]
}