{
  "id": 16358,
  "label": "macrophage activation syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015545",
  "properties": {
    "xrefs": [
      "EFO:1001806",
      "GARD:0012124",
      "MEDGEN:242753",
      "MESH:D055501",
      "MedDRA:10053867",
      "NCIT:C114471",
      "Orphanet:158061",
      "SCTID:430478003",
      "UMLS:C1096155"
    ],
    "synonyms": [
      "MAS",
      "reactive hemophagocytic lymphohistiocytosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16356,
      "label": "secondary hemophagocytic lymphohistiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16354
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020026",
          "MEDGEN:883550",
          "NCIT:C121184",
          "Orphanet:158041",
          "UMLS:C4054044"
        ],
        "synonyms": [
          "acquired hemophagocytic lymphohistiocytosis",
          "acquired hemophagocytic syndrome",
          "reactive hemophagocytic syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015542"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16356,
      "label": "secondary hemophagocytic lymphohistiocytosis"
    }
  ]
}