{
  "id": 16372,
  "label": "Castleman disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015564",
  "properties": {
    "xrefs": [
      "DOID:0111157",
      "GARD:0012656",
      "ICD10CM:D47.Z2",
      "MEDGEN:42211",
      "MESH:D005871",
      "MedDRA:10050251",
      "NCIT:C3056",
      "NORD:898",
      "Orphanet:160",
      "SCTID:207036003",
      "UMLS:C0017531",
      "icd11.foundation:1940989685"
    ],
    "synonyms": [
      "AFLH",
      "Castleman disease",
      "Castleman's disease",
      "Castleman's tumor",
      "Castleman's tumour",
      "GLNH",
      "angiofollicular ganglionic hyperplasia",
      "angiofollicular lymph hyperplasia",
      "angiofollicular lymph node hyperplasia",
      "angiofollicular lymphoid hyperplasia",
      "giant lymph node hyperplasia",
      "ALNH"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form. The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 17033,
      "label": "lymphoproliferative syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5658,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060704",
          "GARD:0020633",
          "MEDGEN:6162",
          "MESH:D008232",
          "NCIT:C9308",
          "OMIMPS:308240",
          "Orphanet:238510",
          "SCTID:277466009",
          "UMLS:C0024314"
        ],
        "synonyms": [
          "lymphoproliferative disorder",
          "lymphoproliferative syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis)."
      },
      "child_count": 16,
      "reference_id": "MONDO:0016537"
    }
  ],
  "children": [
    {
      "id": 19504,
      "label": "pediatric Castleman disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16372
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:93682"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Pediatric Castleman disease (PCD) is a form of Castleman disease (CD) with a predominant occurrence in teenagers which is either asymptomatic or manifest by systemic (such as fever, anemia, fatigue and failure to thrive) or compressive symptoms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019752"
    },
    {
      "id": 19505,
      "label": "localized Castleman disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16372
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006005",
          "MEDGEN:858176",
          "NCIT:C115200",
          "Orphanet:93685",
          "UMLS:C3898582"
        ],
        "synonyms": [
          "localised Angiofollicular lymphoid hyperplasia",
          "localized Angiofollicular lymphoid hyperplasia",
          "localized Castleman disease",
          "Unicentric Castleman disease",
          "Unicentric angiofollicular ganglionic hyperplasia",
          "Unicentric angiofollicular lymph hyperplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Localized Castleman disease (LCD) is the most common form of Castleman disease (CD) and it is usually asymptomatic or it may present with enlarged lymph nodes. LCD may be cured by surgical resection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019753"
    },
    {
      "id": 19506,
      "label": "multicentric Castleman disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16085,
        16372
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111152",
          "GARD:0022310",
          "MEDGEN:233197",
          "NCIT:C27855",
          "Orphanet:570438",
          "Orphanet:93686",
          "UMLS:C1334815",
          "icd11.foundation:1590444463"
        ],
        "synonyms": [
          "HHV-8-associated multicentric Castleman disease",
          "Human herpesvirus-8-associated multicentric Castleman disease",
          "MCD",
          "multicentric Angiofollicular lymphoid hyperplasia",
          "multicentric Castleman's disease",
          "idiopathic multicentric Castleman's disease",
          "multicentric plasma cell variant of Castleman's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019754"
    },
    {
      "id": 22917,
      "label": "idiopathic multicentric Castleman disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16372
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022309",
          "MEDGEN:1680858",
          "Orphanet:570431",
          "UMLS:C5197665"
        ],
        "synonyms": [
          "HHV-8-negative multicentric Castleman disease",
          "Human herpesvirus-8-negative multicentric Castleman disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0035838"
    }
  ],
  "roots": [
    {
      "id": 17033,
      "label": "lymphoproliferative syndrome"
    }
  ]
}